3,3-二甲基-3,4-二氢-1H-喹啉-2-酮合成路线 （共 22 条）
反应条件
palladium diacetate; caesium carbonate; tris-(o-tolyl)phosphine; 2,2,2-trimethylacetic acid in 1-methyl-pyrrolidin-2-one
T=140°C; 48 h; Schlenk technique;
参考文献
Yan, Jia-Xuan; Li, Hu; Liu, Xiang-Wei; Shi, Jiang-Ling; Wang, Xin; Shi, Zhang-Jie
Angewandte Chemie - International Edition, 2014 , vol. 53, # 19 p. 4945 - 4949
反应条件
palladium diacetate; caesium carbonate; tris-(o-tolyl)phosphine; 2,2,2-trimethylacetic acid in 1-methyl-pyrrolidin-2-one
T=140°C; 48 h; Schlenk technique;
参考文献
Yan, Jia-Xuan; Li, Hu; Liu, Xiang-Wei; Shi, Jiang-Ling; Wang, Xin; Shi, Zhang-Jie
Angewandte Chemie - International Edition, 2014 , vol. 53, # 19 p. 4945 - 4949
反应条件
palladium diacetate; caesium carbonate; tris-(o-tolyl)phosphine; 2,2,2-trimethylacetic acid in 1-methyl-pyrrolidin-2-one
T=140°C; 48 h; Schlenk technique;
参考文献
Yan, Jia-Xuan; Li, Hu; Liu, Xiang-Wei; Shi, Jiang-Ling; Wang, Xin; Shi, Zhang-Jie
Angewandte Chemie - International Edition, 2014 , vol. 53, # 19 p. 4945 - 4949
反应条件
3-chloro-benzenecarboperoxoic acid in diethyl ether
96 h;
参考文献
Evans, Andrew R.; Martin, Russell; Taylor, Giles A.; Yap, C. H. Maurice
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1987 , p. 1635 - 1640
反应条件
1: lithium diisopropyl amide / tetrahydrofuran / 12 h / -78 - 20 °C / Inert atmosphere
2: copper(l) iodide; N-acetyl-glycine; potassium iodide; sodium hydroxide / tert-butyl alcohol / 24 h / 100 °C
View Scheme
参考文献
Hsieh, Jen-Chieh; Cheng, An-Yi; Fu, Jun-Hao; Kang, Ting-Wei
Organic and Biomolecular Chemistry, 2012 , vol. 10, # 31 p. 6404 - 6409
反应条件
1: 1.) LDA / 1.) THF, hexane, RT, 1.75 h, 2.) THF, hexane, from -78 deg C to RT, overnight
2: 1.) LDA / 1.) THF, hexane, RT, 1.75 h, 2.) THF, hexane, from -78 deg C to RT, overnight
View Scheme
参考文献
Robertson; Krushinski; Beedle; Wyss; Pollock; Wilson; Kauffman; Hayes
Journal of Medicinal Chemistry, 1986 , vol. 29, # 10 p. 1832 - 1840
反应条件
1: 85 percent / acetic acid / 18 h / Heating
2: 16 percent / m-chloroperoxybenzoic acid / diethyl ether / 96 h
View Scheme
参考文献
Evans, Andrew R.; Martin, Russell; Taylor, Giles A.; Yap, C. H. Maurice
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1987 , p. 1635 - 1640
反应条件
1: 95 percent / sodium, naphthalene / 1,2-dimethoxy-ethane / 1 h / Ambient temperature
2: 85 percent / acetic acid / 18 h / Heating
3: 16 percent / m-chloroperoxybenzoic acid / diethyl ether / 96 h
View Scheme
参考文献
Evans, Andrew R.; Martin, Russell; Taylor, Giles A.; Yap, C. H. Maurice
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1987 , p. 1635 - 1640
反应条件
1: triethylamine / dichloromethane / 0 - 20 °C
2: palladium diacetate; tris-(o-tolyl)phosphine; caesium carbonate; 2,2,2-trimethylacetic acid / 1-methyl-pyrrolidin-2-one / 48 h / 140 °C / |Schlenk technique
View Scheme
参考文献
Yan, Jia-Xuan; Li, Hu; Liu, Xiang-Wei; Shi, Jiang-Ling; Wang, Xin; Shi, Zhang-Jie
Angewandte Chemie - International Edition, 2014 , vol. 53, # 19 p. 4945 - 4949
反应条件
1: triethylamine / dichloromethane / 0 - 20 °C
2: palladium diacetate; tris-(o-tolyl)phosphine; caesium carbonate; 2,2,2-trimethylacetic acid / 1-methyl-pyrrolidin-2-one / 48 h / 140 °C / |Schlenk technique
View Scheme
参考文献
Yan, Jia-Xuan; Li, Hu; Liu, Xiang-Wei; Shi, Jiang-Ling; Wang, Xin; Shi, Zhang-Jie
Angewandte Chemie - International Edition, 2014 , vol. 53, # 19 p. 4945 - 4949
