3,3-二甲基-3,4-二氢-1H-喹啉-2-酮合成路线 （共 22 条）
反应条件
1: triethylamine / dichloromethane / 0 - 20 °C
2: palladium diacetate; tris-(o-tolyl)phosphine; caesium carbonate; 2,2,2-trimethylacetic acid / 1-methyl-pyrrolidin-2-one / 48 h / 140 °C / |Schlenk technique
View Scheme
参考文献
Yan, Jia-Xuan; Li, Hu; Liu, Xiang-Wei; Shi, Jiang-Ling; Wang, Xin; Shi, Zhang-Jie
Angewandte Chemie - International Edition, 2014 , vol. 53, # 19 p. 4945 - 4949
反应条件
lithium diisopropyl amide
1.) THF, hexane, RT, 1.75 h, 2.) THF, hexane, from -78 deg C to RT, overnight; Yield given. Multistep reaction;
参考文献
Robertson; Krushinski; Beedle; Wyss; Pollock; Wilson; Kauffman; Hayes
Journal of Medicinal Chemistry, 1986 , vol. 29, # 10 p. 1832 - 1840
