(3S,4r)-1-(叔丁氧基羰基)-4-(4-氟苯基)哌啶-3-羧酸合成路线 （共 4 条）
反应条件
potassium permanganate; water in tert-butyl alcohol
T=20°C; 4 h;
参考文献
CONCERT PHARMACEUTICALS INC.
Patent: WO2007/16431 A2, 2007 ;
Location in patent: Page/Page column 56 ;
WO 2007/016431 A2
反应条件
1: With sodium hydroxide in 1,4-dioxane; water
T=0 - 20°C; pH=8; 4 h;
2: With hydrogenchloride in water
T=0°C; pH=1;
参考文献
Bachmann, Stephan; Scalone, Michelangelo; Schnider, Patrick
Patent: US2007/232653 A1, 2007 ;
Location in patent: Page/Page column 33 ;
反应条件
1: With sodium methylate in toluene
Heating / reflux;
2: With sodium hydroxide; water in 1,4-dioxane
T=20°C; 5 h;
3: With hydrogenchloride in water
T=0°C; pH=1 - 2; Product distribution / selectivity;
参考文献
Bachmann, Stephan; Scalone, Michelangelo; Schnider, Patrick
Patent: US2007/232653 A1, 2007 ;
Location in patent: Page/Page column 33 ;
反应条件
1: With dimethylsulfide borane complex in tetrahydrofuran
T=0 - 20°C;
2: With methanol in tetrahydrofuran
T=0°C;
参考文献
Grundschober, Christophe; Schnider, Patrick
Patent: US2007/232652 A1, 2007 ;
Location in patent: Page/Page column 15 ;
US 20070232652 A1
