1-乙酰基-4-(4-氨基苯基)哌嗪合成路线 （共 7 条）
参考文献
Al-Horani, Rami A.; Mehta, Akul Y.; Desai, Umesh R.
European Journal of Medicinal Chemistry, 2012 , vol. 54, p. 771 - 783
反应条件
acetic anhydride; triethylamine in dichloromethane
参考文献
US2004/87575 A1, ;
US 20040087575 A1
反应条件
1: N,N-diisopropylethylamine / acetonitrile / 14 h / Heating 2: H2 / Ra-Ni / tetrahydrofuran / 5 h / 20 °C / 2585.74 Torr View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 48, # 7 p. 2371 - 2387
反应条件
in acetonitrile T=20°C; 8 h;
参考文献
Stefane, Bogdan; Ernigoj, Urh; Kocevar, Marijan; Polanc, Slovenko
Tetrahedron Letters, 2001 , vol. 42, # 38 p. 6659 - 6662
反应条件
1: N,N-diisopropylethylamine / acetonitrile / 14 h / Heating 2: H2 / Ra-Ni / tetrahydrofuran / 5 h / 20 °C / 2585.74 Torr View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 48, # 7 p. 2371 - 2387
反应条件
1: palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'- binaphthyl / toluene / 90 °C / Inert atmosphere 2: palladium 10 on activated carbon; hydrogen / 2585.81 Torr View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 46, # 7 p. 2917 - 2929
反应条件
1: pyridine / dichloromethane / 4 h / 20 °C / Inert atmosphere 2: hydrogenchloride; palladium 10 on activated carbon; hydrogen / methanol; water / 5 h / 20 °C View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 54, p. 771 - 783
