3,3-二甲基丙烯酸甲酯合成路线 （共 110 条）
反应条件
1: concentrated sulfuric acid / 160 °C
2: sodium; amyl alcohol
3: aqueous phosphoric acid / 140 °C
View Scheme
参考文献
Colonge et al.
Bulletin de la Societe Chimique de France, 1957 , p. 776,777
反应条件
1: 1) lithium diisopropylamide / 1) THF, -70 deg C, 1 h, 2) r.t., 2 h
2: HBr(gaseous) / CHCl3 / 6 h
3: 74 percent / 1,8-diazabicyclo<5.4.0>undec-7-ene (DBU) / benzene / 24 h / Heating
4: 82 percent / trimethylsilyl iodide / CCl4 / 14 h / Heating
View Scheme
参考文献
Ceccherelli, Paolo; Curini, Massimo; Marcotullio, Maria Carla; Rosati, Ornelio; Wenkert, Ernest
Journal of Organic Chemistry, 1991 , vol. 56, # 25 p. 7065 - 7070
反应条件
1: (i) LDA*HMPT, THF, (ii) /BRN= 1071199/
2: LDA*HMPT / tetrahydrofuran
View Scheme
参考文献
Brocksom,T.J. et al.
Synthetic Communications, 1977 , vol. 7, p. 483 - 493
参考文献
Shustov, G. V.; Tavakalyan, N. B.; Kostyanovsky, R. G.
Tetrahedron, 1985 , vol. 41, # 3 p. 575 - 584
反应条件
1: phenol; concentrated sulfuric acid / 160 °C
2: sodium; amyl alcohol
3: aqueous phosphoric acid / 140 °C
View Scheme
参考文献
Colonge et al.
Bulletin de la Societe Chimique de France, 1957 , p. 776,777
反应条件
1: 220 °C / Microwave irradiation
2: lithium aluminium tetrahydride / tetrahydrofuran / Reflux
View Scheme
参考文献
Wu, Lingyun; Lu, Kai; Desai, Mahesh; Packiarajan, Mathivanan; Joshi, Amita; Marzabadi, Mohammad R.; Jubian, Vrej; Andersen, Kim; Chandrasena, Gamini; Boyle, Noel J.; Walker, Mary W.
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 18 p. 5573 - 5576
反应条件
tetraethylammonium p-toluenesulfonate in acetonitrile
(electrochemical reduction);
参考文献
Shono,T. et al.
Journal of the American Chemical Society, 1977 , vol. 99, p. 7396 - 7397
反应条件
1: 73 percent / Br2 / CH2Cl2 / 10 h / 0 °C
2: 89 percent / DBU / tetrahydrofuran / 1.5 h / -78 °C
3: 71 percent / tetrahydrofuran; diethyl ether / 8 h / 0 °C
View Scheme
参考文献
Mori, Hajime; Ikoma, Keiichi; Katsumura, Shigeo
Chemical Communications, 1997 , # 22 p. 2243 - 2244
反应条件
1: 70 percent / 95 °C
2: 50 percent / potassium hydroxide / toluene
3: 4-toluenesulfonic acid / toluene / Heating
4: H2 / Pd on charcoal
View Scheme
参考文献
Schmitz, E.; Sonnenschein, H.; Kuban, R. J.
Tetrahedron Letters, 1985 , vol. 26, # 40 p. 4911 - 4914
反应条件
bromine in dichloromethane
T=0°C; 10 h;
参考文献
Mori, Hajime; Ikoma, Keiichi; Isoe, Sachihiko; Kitaura, Kazuo; Katsumura, Shigeo
Journal of Organic Chemistry, 1998 , vol. 63, # 24 p. 8704 - 8718
