3,3-二甲基丙烯酸甲酯合成路线 （共 110 条）
反应条件
hydrogenchloride; hydroxylamine hydrochloride 2.) CH2Cl2, water, 100 deg C, 1 h; Yield given. Multistep reaction;
参考文献
Lohaus; Dittmar
Arzneimittel-Forschung/Drug Research, 1981 , vol. 31, # 8 a p. 1311 - 1316
反应条件
1.1: 75 percent / Triton B; piperidine / methanol / 24 h / 60 °C 2.1: LDA / tetrahydrofuran / 12 h 2.2: 40 percent / aq. H2SO4 / 70 h / Heating View Scheme
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2008/118724 A1, 2008 ;
WO 2008/118724 A1
反应条件
(i) AlCl3, (ii) NaOH, MeOH; Multistep reaction;
参考文献
Chemische Berichte, , vol. 100, # 2 p. 658 - 677
反应条件
1: LiAlH4 / diethyl ether 2: 48percent HBr, conc. H2SO4 View Scheme
参考文献
Talapatra, Bani; Roy, Monoj K.; Talapatra, Sunil K.
Journal of the Indian Chemical Society, 1983 , vol. 60, p. 1169 - 1171
反应条件
1: NBS 2: potassium t-butoxide / tetrahydrofuran; various solvent(s) / 1 h / -65 °C 3: potassium hydroxide / methanol / 2.5 h / Heating View Scheme
参考文献
Arnould, Daniel; Chabardes, Pierre; Farge, Guy; Julia, Marc
Bulletin de la Societe Chimique de France, 1985 , # 1 p. 130 - 131
反应条件
hydroxylamine hydrochloride; sodium acetate 2.) water, methanol, 25 deg C, 20 h; Yield given. Multistep reaction;
参考文献
Lohaus; Dittmar
Arzneimittel-Forschung/Drug Research, 1981 , vol. 31, # 8 a p. 1311 - 1316
反应条件
1: NBS / CCl4 / Irradiation 2: K2CO3 / tetrahydrofuran / 8 h / Ambient temperature 3: 1.) n-Bu2CuLi / 1.) THF, -30 deg C, 20 min, 2.) 30 min 4: 95 percent / LiAlH4 View Scheme
参考文献
Calo, Vincenzo; Lopez, Luigi; Pesce, Giannangelo
Gazzetta Chimica Italiana, 1990 , vol. 120, # 3 p. 203 - 205
反应条件
zinc copper in methanol 24 h; Heating;
参考文献
Sondengam, B. Lucas; Fomum, Z. Tanee; Charles, Georges; Akam, T. Mac
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , p. 1219 - 1222
反应条件
1: AlCl3 / CH2Cl2 2: AcOH; H2SO4 View Scheme
参考文献
Chattapadhyay, Tarun Kumar; Dureja, Prem
Journal of Agricultural and Food Chemistry, 2006 , vol. 54, # 6 p. 2129 - 2133
反应条件
lithium aluminium tetrahydride in diethyl ether Yield given;
参考文献
Talapatra, Bani; Roy, Monoj K.; Talapatra, Sunil K.
Journal of the Indian Chemical Society, 1983 , vol. 60, p. 1169 - 1171
