3,3-二甲基丙烯酸甲酯合成路线 （共 110 条）
反应条件
1: 14 g / lithium diisopropylamide / tetrahydrofuran; hexane / cooling 2: 10.5 g / TMSOTf / CH2Cl2 / 16 h / -78 °C 3: 1.69 g / BF3*Et2O / CH2Cl2 / -78 - 20 °C View Scheme
参考文献
Van Innis, Livia; Plancher, Jean Marc; Marko, Istvan E.
Organic Letters, 2006 , vol. 8, # 26 p. 6111 - 6114
反应条件
1: 41 percent / xylene / 15 h / 140 °C 2: 90 percent / LiALH4 / tetrahydrofuran / 3.5 h / Ambient temperature 3: 91 percent / pyridine / 48 h / Ambient temperature 4: 80 percent / LiAlH4 / tetrahydrofuran / 1 h / Heating 5: 89 percent / toluene / 17 h / Heating 6: 1.) MeI, 2.) tert-BuOK / 1.) toluene, 70 deg C, 20 h, 2.) tert-BuOH, reflux, 5 h 7: 91 percent / pyridinium chlorochromate / CH2Cl2 / 3 h / Ambient temperature 8: 88 percent / CH2Cl2 / 18 h / Ambient temperature 9: 1.) n-BuLi / 1.) THF, n-hexane, -78 deg C, 5 min, 2.) THF, n-hexane, -78 deg C, 2 h View Scheme
参考文献
Baggiolini, Enrico G.; Iacobelli, Jerome A.; Hennessy, Bernard M.; Batcho, Andrew D.; Sereno, John F.; Uskokovic, Milan R.
Journal of Organic Chemistry, 1986 , vol. 51, # 16 p. 3098 - 3108
反应条件
1.1: Br2 / CCl4 / 1 h / 25 °C 1.2: 77 percent / Et3N / CH2Cl2 / 0 - 25 °C 2.1: 40 percent / NBS / CCl4 / Irradiation 3.1: 48 percent / conc. HBr (48 percent) / 8 h / Heating View Scheme
参考文献
Lloveras, Maia; Ramos, Isabel; Molins, Elies; Messeguer, Angel
Tetrahedron, 2000 , vol. 56, # 21 p. 3391 - 3397
反应条件
1: AlCl3 / CH2Cl2 2: AcOH; H2SO4 View Scheme
参考文献
Chattapadhyay, Tarun Kumar; Dureja, Prem
Journal of Agricultural and Food Chemistry, 2006 , vol. 54, # 6 p. 2129 - 2133
反应条件
1: N-bromosuccinimude, azobisisobutyronitrile / acetic acid / 3 h / Heating 2: calcium carbonate / methanol / 120 h / Heating 3: 1.) LDA / tetrahydrofuran; hexane / 1.) 0 deg C, 15 min; 2.) -78 deg C, 15 min, then -> room temp., 45 min 4: benzene / 4 h / Ambient temperature 5: conc. HCl, sat. sodium acetate / methanol / 2 h / 40 °C View Scheme
参考文献
Cameron, Donald W.; Gan, Chee-Yong; Griffiths, Peter G.; Pattermann, Judy A.
Australian Journal of Chemistry, 1998 , vol. 51, # 5 p. 421 - 432
反应条件
N,N,N',N',N'',N''-hexamethylphosphoric triamide; lithium diisopropyl amide 1a) THF, -78 deg C, 1b) 0 deg C, 2) THF, 16 h, RT; Yield given. Multistep reaction;
参考文献
Caron; Brassard
Tetrahedron, 1993 , vol. 49, # 4 p. 771 - 784
反应条件
1: 1.) LDA, HMPA / 1.) THF, -78 deg C, 2.) THF, -78 deg C
2: 71 percent / LiAlH4 / diethyl ether / 0 °C
View Scheme
参考文献
Nishigaichi, Yutaka; Yoshikawa, Miyuki; Takigawa, Yasuyo; Takuwa, Akio
Chemistry Letters, 1996 , # 11 p. 961 - 962
反应条件
1: 64.4 percent / NBS, azo-bis-isobutyronitrile / CCl4 / 2 h / Heating
2: Ag2O / H2O / 48 h / Ambient temperature
View Scheme
参考文献
Young, H.; Letham, D. S.; Hocart, C. H.; Eichholzer, J. V.
Phytochemistry (Elsevier), 1990 , vol. 29, # 2 p. 385 - 386
反应条件
1: piperidine / 8826090 Torr
2: aq. HCl / acetone
View Scheme
参考文献
Kurth,H.-J. et al.
Justus Liebigs Annalen der Chemie, 1977 , p. 1141 - 1145
参考文献
Chervin, I. I.; Nasibov, Sh. S.; Rudchenko, V. F.; Shtamburg, V. G.; Kostyanovskii, R. G.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1981 , vol. 30, # 3 p. 389 - 396
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1981 , # 3 p. 544 - 552
