3,3-二甲基丙烯酸甲酯合成路线 （共 110 条）
反应条件
2: (i) naphthalene-Li, (ii) MeOH
View Scheme
参考文献
Cohen,T. et al.
Journal of Organic Chemistry, 1979 , vol. 44, # 20 p. 3599 - 3601
反应条件
1: β,β-dimethyl-acrylic acid methyl ester With sodium hexamethyldisilazane in tetrahydrofuran
T=-78°C; Inert atmosphere;
2: chloro-trimethyl-silane in tetrahydrofuran
T=-78 - 20°C; Inert atmosphere;
参考文献
Troast, Dawn M.; Yuan, Jiayi; Porco Jr., John A.
Advanced Synthesis and Catalysis, 2008 , vol. 350, # 11-12 p. 1701 - 1711
参考文献
Paterson, Ian; Price, Lee G.
Tetrahedron Letters, 1981 , vol. 22, # 29 p. 2833 - 2836
反应条件
pyridine in chloroform
6 h; Heatingohter α,β-unsaturated compounds; Product distributionMechanism;
参考文献
Bhongle, N. N.; Gogte, V. N.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1983 , vol. 22, # 7 p. 632 - 636
反应条件
1-aza-bicyclo[2.2.2]octane; osmium(VIII) oxide; tert-butyl alcohol in acetone
T=25°C; 12 h;
参考文献
Nicolaou; Snyder, Scott A.; Longbottom, Deborah A.; Nalbandian, Annie Z.; Huang, Xianhai
Chemistry - A European Journal, 2004 , vol. 10, # 22 p. 5581 - 5606
反应条件
methanesulfonic acid
T=90°C; 2 h;
参考文献
PROMEGA CORPORATION; BENINK, Helene; CALI, James, J.; DUELLMAN, Sarah; KLAUBERT, Dieter; LEIPPE, Donna; O'BRIEN, Martha; SHULTZ, John; VIDUGIRIENE, Jolanta; ZHOU, Wenhui; SOBOL, Mary
Patent: WO2013/33515 A1, 2013 ;
Location in patent: Paragraph 00171 ;
反应条件
sulfuric acid in benzene
8 h; Heating;
参考文献
King, Michael M.; Cohen, Louis A.
Journal of the American Chemical Society, 1983 , vol. 105, # 9 p. 2752 - 2760
反应条件
1: 43 percent / Bu4NF; molecular sieves 4 Angstroem / tetrahydrofuran / 20 °C
2: 45 percent / zinc; formic acid / ethanol / 20 °C
View Scheme
参考文献
Kim, Han-Je; Dogutan, Dilek Kiper; Ptaszek, Marcin; Lindsey, Jonathan S.
Tetrahedron, 2007 , vol. 63, # 1 p. 37 - 55
反应条件
1: 43 percent / Bu4NF; molecular sieves 4 Angstroem / tetrahydrofuran / 20 °C
2: 45 percent / zinc; formic acid / ethanol / 20 °C
3: 43 percent / Lawesson's reagent / toluene / Heating
View Scheme
参考文献
Kim, Han-Je; Dogutan, Dilek Kiper; Ptaszek, Marcin; Lindsey, Jonathan S.
Tetrahedron, 2007 , vol. 63, # 1 p. 37 - 55
反应条件
sulfuric acid
T=160°C;
参考文献
Colonge et al.
Bulletin de la Societe Chimique de France, 1957 , p. 776,777
