3-(二甲氨基)丙烯酸乙酯合成路线 （共 18 条）
参考文献
Annales de Chimie (Cachan, France), , vol. <10> 18, p. 133
Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, , vol. 190, p. 269
反应条件
1: Et3N / toluene / 1 h / 90 °C 2: 94 percent / ethanol; diethyl ether / 0.25 h / Ambient temperature 3: 92 percent / K2CO3 / dimethylformamide / 1 h / 100 °C View Scheme
参考文献
Cecchetti; Clementi; Cruciani; Fravolini; Pagella; Savino; Tabarrini
Journal of Medicinal Chemistry, 1995 , vol. 38, # 6 p. 973 - 982
反应条件
1: 3-(dimethylamino)acrylic acid ethyl ester; difluoroacetic acid fluoride in toluene T=0 - 3°C; 2: 2-(difluoroacetyl)-3-(dimethylamino)-acrylic acid ethyl ester; methylhydrazine in toluene T=-20 - 25°C;
参考文献
US2010/204483 A1, ;
Page/Page column 5 ;
反应条件
1: 2,4-difluoro-5-iodobenzoic acid With oxalyl dichloride; N,N-dimethyl-formamide in toluene
T=20°C; 12 h;
2: 3-(dimethylamino)acrylic acid ethyl ester With triethylamine in tetrahydrofuran; toluene
1 h; Heating / reflux; Product distribution / selectivity;
参考文献
JAPAN TOBACCO INC.
Patent: WO2005/113509 A1, 2005 ;
Location in patent: Page/Page column 117-118 ;
反应条件
triethylamine in tetrahydrofuran
1 - 15 h; Heating / reflux; Product distribution / selectivity;
参考文献
Sato, Motohide; Kawakami, Hiroshi; Motomura, Takahisa; Aramaki, Hisateru; Matsuda, Takashi; Yamashita, Masaki; Ito, Yoshiharu; Matsuzaki, Yuji; Yamataka, Kazunobu; Ikeda, Satoru; Shinkai, Hisashi
Journal of Medicinal Chemistry, 2009 , vol. 52, # 15 p. 4869 - 4882
反应条件
1: triethylamine / chloroform
2: 1-methyl-pyrrolidin-2-one; potassium tert-butylate / tert-butyl alcohol
View Scheme
参考文献
Taghavi-Moghadam, Shahriyar; Kleemann, Axel; Golbig, Klaus Georg
Organic Process Research and Development, 2001 , vol. 5, # 6 p. 652 - 658
反应条件
1.1: triethylamine / toluene / 3 h / 90 °C / |Inert atmosphere
2.1: ethanol; diethyl ether / 2 h / 20 °C / |Inert atmosphere
2.2: 2 h / 100 °C / |Inert atmosphere
View Scheme
参考文献
GLAXO GROUP LIMITED; SHIONOGI and CO., LTD.; LIAO, Xiangmin; PEARSON, Neil, David; PENDRAK, Israil; SANO, Masayuki
Patent: WO2013/52568 A1, 2013 ;
反应条件
ammonium acetate; acetic acid
Reflux;
参考文献
Al-Awadi, Nouria A.; Ibrahim, Maher R.; Elnagdi, Mohamed H.; John, Elizabeth; Ibrahim, Yehia A.
Beilstein Journal of Organic Chemistry, 2012 , vol. 8, p. 441 - 447
