2-苯基-1H-苯并咪唑-1-乙酸合成路线 （共 4 条）
反应条件
1.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 20 °C / |Inert atmosphere
1.2: 16 h / 20 °C
2.1: sodium hydroxide / methanol / 20 °C / |Inert atmosphere
View Scheme
参考文献
KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY; PAE, Ae Nim; MIN, Sun Joon; ROH, Eun Joo; YANG, Ha Yun; KIM, Tae Hoon; PARK, Beoung Gun; CHO, Yong Seo
Patent: US2014/114067 A1, 2014 ;
反应条件
1.1: sodium carbonate / tetrahydrofuran / 0 - 20 °C / |Inert atmosphere
2.1: L-proline; sodium hydroxide; ammonia; copper(l) iodide / dimethyl sulfoxide; water / 2 h / |Inert atmosphere
2.2: 7 h / 80 °C
3.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 20 °C / |Inert atmosphere
3.2: 16 h / 20 °C
4.1: sodium hydroxide / methanol / 20 °C / |Inert atmosphere
View Scheme
参考文献
KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY; PAE, Ae Nim; MIN, Sun Joon; ROH, Eun Joo; YANG, Ha Yun; KIM, Tae Hoon; PARK, Beoung Gun; CHO, Yong Seo
Patent: US2014/114067 A1, 2014 ;
反应条件
1.1: L-proline; sodium hydroxide; ammonia; copper(l) iodide / dimethyl sulfoxide; water / 2 h / |Inert atmosphere
1.2: 7 h / 80 °C
2.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 20 °C / |Inert atmosphere
2.2: 16 h / 20 °C
3.1: sodium hydroxide / methanol / 20 °C / |Inert atmosphere
View Scheme
参考文献
KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY; PAE, Ae Nim; MIN, Sun Joon; ROH, Eun Joo; YANG, Ha Yun; KIM, Tae Hoon; PARK, Beoung Gun; CHO, Yong Seo
Patent: US2014/114067 A1, 2014 ;
反应条件
1.1: sodium carbonate / tetrahydrofuran / 0 - 20 °C / |Inert atmosphere
2.1: L-proline; sodium hydroxide; ammonia; copper(l) iodide / dimethyl sulfoxide; water / 2 h / |Inert atmosphere
2.2: 7 h / 80 °C
3.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 20 °C / |Inert atmosphere
3.2: 16 h / 20 °C
4.1: sodium hydroxide / methanol / 20 °C / |Inert atmosphere
View Scheme
参考文献
KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY; PAE, Ae Nim; MIN, Sun Joon; ROH, Eun Joo; YANG, Ha Yun; KIM, Tae Hoon; PARK, Beoung Gun; CHO, Yong Seo
Patent: US2014/114067 A1, 2014 ;
