2-甲基-1-苯基-1H-苯并咪唑-5-羧酸合成路线 （共 4 条）
反应条件
1: With hydrogenchloride in toluene 2.75 h; Reflux; 2: With sodium hydroxide in water; toluene T=20°C; 3: With hydrogenchloride in water T=5 - 10°C; pH=~ 4;
参考文献
Sumitomo Chemical Company, Limited
Patent: EP2436683 A1, 2012 ;
Location in patent: Page/Page column 44 ;
反应条件
1.1: ethanol / 16 h / Reflux 2.1: hydrogen / palladium 10 on activated carbon / tetrahydrofuran / 2.5 h / 20 °C 3.1: hydrogenchloride / toluene / 2.75 h / Reflux 3.2: 20 °C 3.3: 5 - 10 °C / pH ~ 4 View Scheme
反应条件
1.1: hydrogen / palladium 10 on activated carbon / tetrahydrofuran / 2.5 h / 20 °C 2.1: hydrogenchloride / toluene / 2.75 h / Reflux 2.2: 20 °C 2.3: 5 - 10 °C / pH ~ 4 View Scheme
反应条件
1.1: ethanol / 16 h / Reflux 2.1: hydrogen / palladium 10 on activated carbon / tetrahydrofuran / 2.5 h / 20 °C 3.1: hydrogenchloride / toluene / 2.75 h / Reflux 3.2: 20 °C 3.3: 5 - 10 °C / pH ~ 4 View Scheme
