2-氨基-5-[(3,4,5-三甲氧基苯基)甲基]-1H-嘧啶-4-酮合成路线 （共 4 条）
反应条件
1: 3-(3,4,5-trimethoxyphenyl)propionic acid ethyl ester; formic acid ethyl ester With sodium in diethyl ether; toluene
T=0°C; 24 h;
2: guanidinium carbonate With sodium methylate in methanol
48 h; Heating;
参考文献
Hess; Doelker; Haferburg; Kertscher; Matysik; Ortwein; Teubert; Zimmermann; Eger
Pharmazie, 2001 , vol. 56, # 4 p. 306 - 310
反应条件
in water
Heating; Further byproducts given;
参考文献
Bergh; Breytenbach; Wessels
Journal of Pharmaceutical Sciences, 1989 , vol. 78, # 4 p. 348 - 350
反应条件
pH 7.0
T=86°C; var. pH, temp., ΔH(excit.), ΔS(excit.); Rate constantThermodynamic dataMechanism;
参考文献
Bergh; Breytenbach; Breet
Pharmazie, 1997 , vol. 52, # 4 p. 290 - 294
反应条件
trichlorophosphate
8 h; Heating;
参考文献
Hess; Doelker; Haferburg; Kertscher; Matysik; Ortwein; Teubert; Zimmermann; Eger
Pharmazie, 2001 , vol. 56, # 4 p. 306 - 310
