双(2,2,2-三氟乙基)亚磷酸酯合成路线 （共 12 条）
反应条件
tert-butyl alcohol; phosphorus trichoride in dichloromethane 15 h;
参考文献
Timperley; Waters
Chemical Communications, 2001 , # 9 p. 797 - 798
反应条件
tert-butyl alcohol; phosphorus trichoride in dichloromethane T=25°C; 16 h;
参考文献
Gibbs, Don E.; Larsen, Catherine
Synthesis, 1984 , # 5 p. 410 - 413
参考文献
Mironov, V. F.; Konovalova, I. V.
Russian Journal of General Chemistry, 1993 , vol. 63, # 10.1 p. 1548 - 1550
Zhurnal Obshchei Khimii, 1993 , vol. 63, # 10 p. 2228 - 2232
参考文献
Mironov, V. F.; Konovalova, I. V.
Russian Journal of General Chemistry, 1993 , vol. 63, # 10.1 p. 1548 - 1550
Zhurnal Obshchei Khimii, 1993 , vol. 63, # 10 p. 2228 - 2232
反应条件
1: Bis(2,2,2-trifluoroethyl) phosphonate With N,N,N',N',N'',N''-hexamethylphosphoric triamide; sodium hydride in tetrahydrofuran T=20°C; Metallation; 2: ethyl α-bromobutyrate in tetrahydrofuran; N,N,N',N',N'',N''-hexamethylphosphoric triamide T=20°C; Michaelis-Becker reaction; 9 h;
参考文献
Ciszewski, Gregory M.; Jackson, John A.
Organic Preparations and Procedures International, 1999 , vol. 31, # 2 p. 240 - 243
反应条件
1: Bis(2,2,2-trifluoroethyl) phosphonate With sodium hydride in toluene T=0 - 25°C; Michaelis-Becker reaction; 2: monobromoacetic acid in toluene T=0 - 25°C; Michaelis-Becker reaction; Inert atmosphere;
参考文献
Dasilvaprado, Viviana; Burtoloso, Antonio Carlos B.
Synthesis, 2010 , # 2 art. no. M03409SS, p. 361 - 363
反应条件
1,8-diazabicyclo[5.4.0]undec-7-ene in acetonitrile T=0 - 20°C; 2 h;
参考文献
Gavara, Laurent; Petit, Christelle; Montchamp, Jean-Luc
Tetrahedron Letters, 2012 , vol. 53, # 37 p. 5000 - 5003
反应条件
1: Bis(2,2,2-trifluoroethyl) phosphonate With sodium hydride in tetrahydrofuran T=20°C; 0.5 h; 2: maleic acid dimethyl ester in tetrahydrofuran 0.5 h; 3: 4-methyl-benzaldehyde in tetrahydrofuran 3 h;
参考文献
Shen, Yanchang; Zhang, Yuming
Heteroatom Chemistry, 2003 , vol. 14, # 3 p. 276 - 279
反应条件
1: Bis(2,2,2-trifluoroethyl) phosphonate With N,N,N',N',N'',N''-hexamethylphosphoric triamide; sodium hydride in tetrahydrofuran T=20°C; Metallation; 2: 2-bromopropanoic acid ethyl ester in tetrahydrofuran; N,N,N',N',N'',N''-hexamethylphosphoric triamide T=20°C; Michaelis-Becker reaction; 5 h;
参考文献
Ciszewski, Gregory M.; Jackson, John A.
Organic Preparations and Procedures International, 1999 , vol. 31, # 2 p. 240 - 243
反应条件
1: Bis(2,2,2-trifluoroethyl) phosphonate With sodium hydride in tetrahydrofuran T=-42°C; Metallation; 2: ethyl bromoacetate in tetrahydrofuran T=20°C; Michaelis-Becker reaction; 5 h;
参考文献
Ciszewski, Gregory M.; Jackson, John A.
Organic Preparations and Procedures International, 1999 , vol. 31, # 2 p. 240 - 243
