2,5-双(4,4,5,5-四甲基-1,3,2-二噁硼烷-2-基)噻吩并[3,2-b]噻吩合成路线 （共 2 条）
反应条件
1: thieno[3,2-b]thiophene With n-butyllithium in tetrahydrofuran; hexanes
T=-78°C; 1.16667 h; Inert atmosphereCooling with ice;
2: 2-isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane in tetrahydrofuran; hexanes
3: With ammonium chloride in tetrahydrofuran; hexanes; water
参考文献
VERTEX PHARMACEUTICALS INCORPORATED; DAS, Sanjoy Kumar; BENNANI, Youssef L.
Patent: WO2011/119853 A1, 2011 ;
Location in patent: Page/Page column 126-127 ;
反应条件
1: 2,5-dibromothienolt;3,2-bgt;thiophene With n-butyllithium in tetrahydrofuran; hexane
T=-70°C; 1 h; Inert atmosphere;
2: 2-isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane in tetrahydrofuran; hexane
T=-70°C; Inert atmosphere;
参考文献
Bijleveld, Johan C.; Verstrijden, R. A. Melanie; Wienk, Martijn M.; Janssen, Rene A. J.
Journal of Materials Chemistry, 2011 , vol. 21, # 25 p. 9224 - 9231
