4-甲氧基-2-甲基-联苯合成路线 （共 109 条）
反应条件
1.1: 73 percent / diethyl ether / 0 - 20 °C
2.1: TBAF / tetrahydrofuran
2.2: 89 percent / TBAF; (t-Bu)3P / [(allyl)PdCl]2 / tetrahydrofuran / 3 h / Heating
View Scheme
参考文献
Denmark, Scott E.; Wu, Zhicai
Organic Letters, 1999 , vol. 1, # 9 p. 1495 - 1498
反应条件
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; water; potassium carbonate in dimethyl sulfoxide
T=110°C; Hiyama coupling;
参考文献
Shirbin, Steven J.; Boughton, Berin A.; Zammit, Steven C.; Zanatta, Shannon D.; Marcuccio, Sebastian M.; Hutton, Craig A.; Williams, Spencer J.
Tetrahedron Letters, 2010 , vol. 51, # 22 p. 2971 - 2974
反应条件
1,3-bis-(diphenylphosphino)propane; potassium carbonate; nickel dichloride in 1,4-dioxane
T=100°C; Suzuki-Miyaura coupling; Inert atmosphere;
参考文献
Zhao, Yu-Long; Li, You; Li, Yu; Gao, Lian-Xun; Han, Fu-She
Chemistry - A European Journal, 2010 , vol. 16, # 17 p. 4991 - 4994
反应条件
tetrabutyl ammonium fluoride; bis(dibenzylideneacetone)-palladium(0); 2-dicyclohexylphosphino-1,1'-biphenyl in 1,4-dioxane
6 h; Heating;
参考文献
Seganish, W. Michael; DeShong, Philip
Journal of Organic Chemistry, 2004 , vol. 69, # 4 p. 1137 - 1143
反应条件
in tetrahydrofuran
T=110°C; Inert atmosphere;
参考文献
Minami, Hiroki; Wang, Xuan; Wang, Chao; Uchiyama, Masanobu
European Journal of Organic Chemistry, 2013 , # 35 p. 7891 - 7894
反应条件
1: 2-methylfluorobenzene; p-MeOC6H4ZnCl With Ni(PCy3)2Cl2 in tetrahydrofuran; 1-methyl-pyrrolidin-2-one
T=25 - 100°C; 10 h; Schlenk techniqueInert atmosphere;
2: p-MeOC6H4ZnCl in tetrahydrofuran; 1-methyl-pyrrolidin-2-one
T=100°C; 10 h; Inert atmosphereSchlenk technique;
参考文献
Zhu, Feng; Wang, Zhong-Xia
Journal of Organic Chemistry, 2014 , vol. 79, # 10 p. 4285 - 4292
反应条件
1.1: silicon tetrachloride / diethyl ether / -20 - 20 °C
2.1: 3.5 g / diethyl ether / 12 h / Heating
3.1: tetrabutylammonium fluoride trihydrate / tetrahydrofuran; H2O / 1 h / 20 °C
3.2: 92 percent / 2-dicyclohexylphosphino-2',4',6'-triisopropylbiphenyl / [(η3-C3H5)PdCl]2 / tetrahydrofuran; H2O / 4 h / 80 °C
View Scheme
参考文献
Sahoo, Akhila K.; Oda, Takuro; Nakao, Yoshiaki; Hiyama, Tamejiro
Advanced Synthesis and Catalysis, 2004 , vol. 346, # 13-15 p. 1715 - 1727
反应条件
1: C4H12Zn(2-)*Li(1+); para-iodoanisole in diethyl ether
T=0°C; 0.5 h;
2: 1-bromo-2-iodo-benzene in diethyl ether
T=20°C; 16 h;
3: methyl iodide in diethyl ether
T=20°C; 3 h; Further stages.;
参考文献
Uchiyama, Masanobu; Kobayashi, Yuri; Furuyama, Taniyuki; Nakamura, Shinji; Kajihara, Yumiko; Miyoshi, Tomoko; Sakamoto, Takao; Kondo, Yoshinori; Morokuma, Keiji
Journal of the American Chemical Society, 2008 , vol. 130, # 2 p. 472 - 480
反应条件
bis(1,5-cyclooctadiene)nickel (0); 5-N-(3-benzyl-1-imidazolylium)-4(24),6(10),12(16),18(22)-tetramethylenedioxy-2,8,14, 20-tetra-pentylresorcin[4]arene bromide in tetrahydrofuran; 1,4-dioxane; decane
T=100°C; Kumada Cross-Coupling; 1 h; Schlenk techniqueInert atmosphere;
参考文献
Sahin, Neslihan; Semeril, David; Brenner, Eric; Matt, Dominique; Oezdemir, Ismail; Kaya, Cemal; Toupet, Loic
European Journal of Organic Chemistry, 2013 , # 20 p. 4443 - 4449
反应条件
Yield given. Multistep reaction;
参考文献
Lipshutz, Bruce H.; Seigmann, Konstantin; Garcia, Emiliano
Tetrahedron, 1992 , vol. 48, # 13 p. 2579 - 2588
