4-(2-吗啉-4-基-乙氧基)苯甲酸甲酯合成路线 （共 6 条）
反应条件
1: With lithium hydroxide; water in tetrahydrofuran T=20°C; 2: With hydrogenchloride in tetrahydrofuran; water pH=2;
参考文献
METHYLGENE, INC.
Patent: WO2005/30704 A1, 2005 ;
Location in patent: Page/Page column 207-208 ;
反应条件
potassium carbonate in acetonitrile
T=50°C;
参考文献
METHYLGENE, INC.
Patent: WO2005/30704 A1, 2005 ;
Location in patent: Page/Page column 207-208 ;
反应条件
in N,N-dimethyl-formamide
T=20°C;
参考文献
BIOMARIN PHARMACEUTICAL INC.; CHU, Daniel; WANG, Bing
Patent: WO2011/140009 A1, 2011 ;
Location in patent: Page/Page column 98; 99 ;
反应条件
di-isopropyl azodicarboxylate; triphenylphosphine in tetrahydrofuran
T=0 - 20°C;
参考文献
GLAXO GROUP LIMITED
Patent: WO2006/27211 A1, 2006 ;
Location in patent: Page/Page column 56-57 ;
WO 2006/027211 A1
反应条件
potassium carbonate; butanone
参考文献
Najer et al.
Bulletin de la Societe Chimique de France, 1956 , p. 613,620
反应条件
1: caesium carbonate / N,N-dimethyl-formamide / 60 °C
2: N,N-dimethyl-formamide / 20 °C
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参考文献
BIOMARIN PHARMACEUTICAL INC.; CHU, Daniel; WANG, Bing
Patent: WO2011/140009 A1, 2011 ;
