1-甲基-4-硝基-1H-吡唑-5-羧酸合成路线 （共 12 条）
反应条件
sulfuric acid; nitric acid 1) 30-40 deg C, 1h; 2) 75-80 deg C, 2h;
参考文献
Perevalov, V. P.; Andreeva, M. A.; Manaev, Yu. A.; Isaev, Sh. G.; Baryshnenkova, L. I.; Stepanov, B. I.
Journal of Organic Chemistry USSR (English Translation), 1984 , vol. 20, # 5 p. 976 - 980
Zhurnal Organicheskoi Khimii, 1984 , vol. 20, # 5 p. 1073 - 1078
反应条件
potassium hydroxide in ethanol
参考文献
Regiec, Andrzej; Mastalarz, Henryk; Mastalarz, Agnieszka; Kochel, Andrzej
Tetrahedron Letters, 2009 , vol. 50, # 22 p. 2624 - 2627
反应条件
sulfuric acid; nitric acid T=55°C; nitrodeiodination; 13 h;
参考文献
Tret'yakov; Vasilevsky
Russian Chemical Bulletin, 1996 , vol. 45, # 11 p. 2581 - 2584
反应条件
in methanol T=20 - 40°C;
参考文献
Tetrahedron Letters, , vol. 50, # 22 p. 2624 - 2627
反应条件
1: in N,N-dimethyl-formamide T=20 - 60°C; 2: in N,N-dimethyl-formamide T=40°C;
参考文献
Tetrahedron Letters, , vol. 50, # 22 p. 2624 - 2627
反应条件
1: in methanol T=20 - 60°C; 2: in methanol T=40°C;
参考文献
Tetrahedron Letters, , vol. 50, # 22 p. 2624 - 2627
反应条件
1: 75 percent / potassium permanganate 2: 96 percent / nitric acid (d 1.52), sulfuric acid monohydrate / 1.) 30-40 deg C, 1 h; 2.) 75-80 deg C, 2 h View Scheme
参考文献
Journal of Organic Chemistry USSR (English Translation), , vol. 20, # 5 p. 976 - 980
Zhurnal Organicheskoi Khimii, , vol. 20, # 5 p. 1073 - 1078
反应条件
ammonium hydroxide T=190°C; 5 h; high pressure;
参考文献
Perevalov, V. P.; Andreeva, M. A.; Baryshnenkova, L. I.; Manaev, Yu. A.; Yamburg, G. S.; et al.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1983 , vol. 19, # 12 p. 1326 - 1330
Khimiya Geterotsiklicheskikh Soedinenii, 1983 , vol. 19, # 12 p. 1676 - 1679
反应条件
1: 1.) thionyl chloride; 2.) 25percent aqueous ammonia / 1.) reflux, 4 h; 2.) 10 deg C 2: 84 percent / 95percent hydrazine hydrate / Raney nickel / propan-2-ol / 55 - 60 °C View Scheme
参考文献
Perevalov, V. P.; Andreeva, M. A.; Manaev, Yu. A.; Isaev, Sh. G.; Baryshnenkova, L. I.; Stepanov, B. I.
Journal of Organic Chemistry USSR (English Translation), 1984 , vol. 20, # 5 p. 976 - 980
Zhurnal Organicheskoi Khimii, 1984 , vol. 20, # 5 p. 1073 - 1078
反应条件
hydrogenchloride 16 h; Heating / reflux;
参考文献
KALYPSYS, INC.
Patent: WO2009/26241 A1, 2009 ;
Location in patent: Page/Page column 66-67 ;
WO 2009/026241 A1
