1-(2-氯苄基)-4-哌啶胺合成路线 （共 3 条）
反应条件
bis-[(trifluoroacetoxy)iodo]benzene in water; acetonitrile
T=65°C; Hoffmann rearrangement;
参考文献
Shum; Peet; Weintraub; Le; Zhao; Barbone; Cashman; Tsay; Dwyer; Loos; Powers; Kropp; Wright; Bitonti; Dumont; Borcherding
Nucleosides, Nucleotides and Nucleic Acids, 2001 , vol. 20, # 4-7 p. 1067 - 1078
反应条件
lithium aluminium tetrahydride in tetrahydrofuran; diethyl ether
19 h; Heating;
参考文献
Moragues; Prieto; Spickett; Vega; Salazar; Roberts
Farmaco, Edizione Scientifica, 1980 , vol. 35, # 11 p. 951 - 964
反应条件
1: Cs2CO3; KI / various solvent(s) / 5 h / 100 °C
2: PhI(CF3CO2)2 / acetonitrile; H2O / 65 °C
View Scheme
参考文献
Shum; Peet; Weintraub; Le; Zhao; Barbone; Cashman; Tsay; Dwyer; Loos; Powers; Kropp; Wright; Bitonti; Dumont; Borcherding
Nucleosides, Nucleotides and Nucleic Acids, 2001 , vol. 20, # 4-7 p. 1067 - 1078
