1-(3,4-二氯苄基)-4-哌啶基胺合成路线 （共 6 条）
反应条件
hydrogenchloride in methanol
T=20°C; 20 h;
参考文献
Naya, Akira; Kobayashi, Kensuke; Ishikawa, Makoto; Ohwaki, Kenji; Saeki, Toshihiko; Noguchi, Kazuhito; Ohtake, Norikazu
Chemical and Pharmaceutical Bulletin, 2003 , vol. 51, # 6 p. 697 - 701
反应条件
sodium hydroxide; triethylamine; trifluoroacetic acid in dichloromethane; N,N-dimethyl-formamide
参考文献
Eriksson, Tomas; Klingstedt, Tomas; Mussie, Tesfaledet
Patent: US2003/162772 A1, 2003 ;
反应条件
bis-[(trifluoroacetoxy)iodo]benzene in water; acetonitrile
T=65°C; Hoffmann rearrangement;
参考文献
Shum; Peet; Weintraub; Le; Zhao; Barbone; Cashman; Tsay; Dwyer; Loos; Powers; Kropp; Wright; Bitonti; Dumont; Borcherding
Nucleosides, Nucleotides and Nucleic Acids, 2001 , vol. 20, # 4-7 p. 1067 - 1078
反应条件
1: 72 percent / NaBH(OAc)3 / CHCl3 / 20 h / 20 °C
2: 85 percent / HCl / methanol / 20 h / 20 °C
View Scheme
参考文献
Naya, Akira; Kobayashi, Kensuke; Ishikawa, Makoto; Ohwaki, Kenji; Saeki, Toshihiko; Noguchi, Kazuhito; Ohtake, Norikazu
Chemical and Pharmaceutical Bulletin, 2003 , vol. 51, # 6 p. 697 - 701
反应条件
1: 72 percent / NaBH(OAc)3 / CHCl3 / 20 h / 20 °C
2: 85 percent / HCl / methanol / 20 h / 20 °C
View Scheme
参考文献
Naya, Akira; Kobayashi, Kensuke; Ishikawa, Makoto; Ohwaki, Kenji; Saeki, Toshihiko; Noguchi, Kazuhito; Ohtake, Norikazu
Chemical and Pharmaceutical Bulletin, 2003 , vol. 51, # 6 p. 697 - 701
反应条件
1: Cs2CO3; KI / various solvent(s) / 5 h / 100 °C
2: PhI(CF3CO2)2 / acetonitrile; H2O / 65 °C
View Scheme
参考文献
Shum; Peet; Weintraub; Le; Zhao; Barbone; Cashman; Tsay; Dwyer; Loos; Powers; Kropp; Wright; Bitonti; Dumont; Borcherding
Nucleosides, Nucleotides and Nucleic Acids, 2001 , vol. 20, # 4-7 p. 1067 - 1078
