2: NH3 / methanol / Ambient temperature 3: 93 percent / lithium triethylborohydride / tetrahydrofuran; dimethylsulfoxide / Ambient temperature 4: 61 percent / Et3N, 4-dimethylaminopyridine / dimethylformamide / RT, 5 h; 4 deg C, 60 h 5: 35 percent / DAST / CH2Cl2 / 2 h / Ambient temperature 6: 72 percent / NH3 / methanol / Ambient temperature View Scheme

1: 35 percent / DAST / CH2Cl2 / 2 h / Ambient temperature 2: 72 percent / NH3 / methanol / Ambient temperature View Scheme

1: 93 percent / lithium triethylborohydride / tetrahydrofuran; dimethylsulfoxide / Ambient temperature 2: 61 percent / Et3N, 4-dimethylaminopyridine / dimethylformamide / RT, 5 h; 4 deg C, 60 h 3: 35 percent / DAST / CH2Cl2 / 2 h / Ambient temperature 4: 72 percent / NH3 / methanol / Ambient temperature View Scheme

1: NaNO2 / acetic acid; H2O / Ambient temperature 2: 59 percent / NH3 / methanol / Ambient temperature 3: 93 percent / lithium triethylborohydride / tetrahydrofuran; dimethylsulfoxide / Ambient temperature 4: 61 percent / Et3N, 4-dimethylaminopyridine / dimethylformamide / RT, 5 h; 4 deg C, 60 h 5: 35 percent / DAST / CH2Cl2 / 2 h / Ambient temperature 6: 72 percent / NH3 / methanol / Ambient temperature View Scheme

1: 61 percent / Et3N, 4-dimethylaminopyridine / dimethylformamide / RT, 5 h; 4 deg C, 60 h 2: 35 percent / DAST / CH2Cl2 / 2 h / Ambient temperature 3: 72 percent / NH3 / methanol / Ambient temperature View Scheme

2: pyridine / Ambient temperature 3: 86 percent / NH3 / methanol / Ambient temperature 4: NaNO2 / acetic acid; H2O / Ambient temperature 5: 59 percent / NH3 / methanol / Ambient temperature 6: 93 percent / lithium triethylborohydride / tetrahydrofuran; dimethylsulfoxide / Ambient temperature 7: 61 percent / Et3N, 4-dimethylaminopyridine / dimethylformamide / RT, 5 h; 4 deg C, 60 h 8: 35 percent / DAST / CH2Cl2 / 2 h / Ambient temperature 9: 72 percent / NH3 / methanol / Ambient temperature View Scheme

1: trimethylsilyl trifluoromethanesulfonate / acetonitrile / 18 h / 21 °C / Inert atmosphere 2: 2-hydroxyethanethiol; sodium hydroxide / water / 1.5 h / Inert atmosphere; Reflux; Large scale reaction View Scheme

1.1: H2SO4 / acetic acid / 2.5 h / 0 °C 2.1: aq. HCl / toluene; dioxane; cyclohexane / 8 h / 0 °C 3.1: o-H3PO4; nBu3N; 4 Angstroem molecular sieve / acetonitrile; various solvent(s) / 6 h / 0 °C 3.2: acetonitrile; various solvent(s) 4.1: KOH / H2O / 48 h / 50 °C 5.1: PNPase; CaCl2 / H2O / 5 h / 40 - 60 °C / Enzymatic reaction View Scheme

1.1: o-H3PO4; nBu3N; 4 Angstroem molecular sieve / acetonitrile; various solvent(s) / 6 h / 0 °C 1.2: acetonitrile; various solvent(s) 2.1: KOH / H2O / 48 h / 50 °C 3.1: PNPase; CaCl2 / H2O / 5 h / 40 - 60 °C / Enzymatic reaction View Scheme

1.1: aq. HCl / toluene; dioxane; cyclohexane / 8 h / 0 °C 2.1: o-H3PO4; nBu3N; 4 Angstroem molecular sieve / acetonitrile; various solvent(s) / 6 h / 0 °C 2.2: acetonitrile; various solvent(s) 3.1: KOH / H2O / 48 h / 50 °C 4.1: PNPase; CaCl2 / H2O / 5 h / 40 - 60 °C / Enzymatic reaction View Scheme