1: α-cyanoacetic acid methyl ester With sodium hydride in dimethyl sulfoxide T=20°C; 0.5 h; 2: 4-cyano-3-fluoro-1-bromobenzene in dimethyl sulfoxide T=90°C; 2 h; 3: in water; dimethyl sulfoxide 8 h; Heating; Further stages.;

water in dimethyl sulfoxide T=115°C; 1 h;

1: 74 percent / NaH / dimethylsulfoxide / 90 °C 2: 93 percent / H2O / dimethylsulfoxide / 1 h / 115 °C View Scheme

dichloro-acetic acid; hydrogen bromide T=0 - 20°C;