1: aq. NH4Cl, aq. NH3 2: (i) NaOMe, Et2O, (ii) /BRN= 506456/, Et2O, (iii) aq. H2SO4 View Scheme

1: aq. NH4Cl, aq. NH3 2: (i) NaOMe, Et2O, (ii) /BRN= 506456/, Et2O, (iii) aq. H2SO4 3: polyphosphoric acid / 145 °C View Scheme

ammonium hydroxide; ammonium chloride

1: aq. NH4Cl, aq. NH3 2: (i) NaOMe, Et2O, (ii) /BRN= 506456/, Et2O, (iii) aq. H2SO4 3: polyphosphoric acid / 145 °C 4: NaOMe / benzene 5: (i) Et3N, benzene, (ii) KOH, MeOH 6: p-cymene / Pd-C / Heating 7: K2CO3 / acetone / Heating View Scheme