1: N-ethoxycarbonyl-piperazine; 2-chloro-4-methyl-5-nitropyridine in ethanol T=20°C; 72 h; 2: N,N-dimethyl-formamide dimethyl acetal in N,N-dimethyl-formamide T=90°C; 72 h; 3: With potassium hydroxide; ethanol; water; hydrogen; acetic acid; triethylamine; palladium on activated carbon more than 3 stages;

potassium hydroxide in ethanol; water 48 h; Heating / reflux;