(-)-1,2,3,3a,4,5-六氢吡咯并[1,2-a]喹喔啉合成路线 （共 7 条）
反应条件
lithium aluminium tetrahydride in tetrahydrofuran; diethyl ether
18 h; Heating;
参考文献
Abou-Gharbia, Magid; Freed, Meier E.; McCaully, Ronald J.; Silver, Paul J.; Wendt, Robert L.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 12 p. 1743 - 1746
反应条件
1: 82 percent / triethylamine / dimethylsulfoxide / 18 h / 60 °C
2: glacial acetic acid, iron powder / 3 h / 60 - 65 °C
3: 80 percent / LiAlH4 / diethyl ether; tetrahydrofuran / 18 h / Heating
View Scheme
参考文献
Abou-Gharbia, Magid; Freed, Meier E.; McCaully, Ronald J.; Silver, Paul J.; Wendt, Robert L.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 12 p. 1743 - 1746
反应条件
1: glacial acetic acid, iron powder / 3 h / 60 - 65 °C
2: 80 percent / LiAlH4 / diethyl ether; tetrahydrofuran / 18 h / Heating
View Scheme
参考文献
Abou-Gharbia, Magid; Freed, Meier E.; McCaully, Ronald J.; Silver, Paul J.; Wendt, Robert L.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 12 p. 1743 - 1746
反应条件
1: 82 percent / triethylamine / dimethylsulfoxide / 18 h / 60 °C
2: glacial acetic acid, iron powder / 3 h / 60 - 65 °C
3: 80 percent / LiAlH4 / diethyl ether; tetrahydrofuran / 18 h / Heating
View Scheme
参考文献
Abou-Gharbia, Magid; Freed, Meier E.; McCaully, Ronald J.; Silver, Paul J.; Wendt, Robert L.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 12 p. 1743 - 1746
反应条件
<b>Multi-step reaction with 3 steps<br /> </b>1: 82 percent / triethylamine / dimethylsulfoxide / 18 h / 60 °C<br />2: glacial acetic acid, iron powder / 3 h / 60 - 65 °C<br />3: 80 percent / LiAlH<sub>4</sub> / diethyl ether; tetrahydrofuran / 18 h / Heating<br /> <br />
参考文献
Abou-Gharbia, Magid; Freed, Meier E.; McCaully, Ronald J.; Silver, Paul J.; Wendt, Robert L. Journal of Medicinal Chemistry, 1984 , vol. 27, # 12 p. 1743 - 1746
反应条件
<b>Multi-step reaction with 2 steps<br /> </b>1: glacial acetic acid, iron powder / 3 h / 60 - 65 °C<br />2: 80 percent / LiAlH<sub>4</sub> / diethyl ether; tetrahydrofuran / 18 h / Heating<br /> <br />
参考文献
Abou-Gharbia, Magid; Freed, Meier E.; McCaully, Ronald J.; Silver, Paul J.; Wendt, Robert L. Journal of Medicinal Chemistry, 1984 , vol. 27, # 12 p. 1743 - 1746
反应条件
<b>Multi-step reaction with 3 steps<br /> </b>1: 82 percent / triethylamine / dimethylsulfoxide / 18 h / 60 °C<br />2: glacial acetic acid, iron powder / 3 h / 60 - 65 °C<br />3: 80 percent / LiAlH<sub>4</sub> / diethyl ether; tetrahydrofuran / 18 h / Heating<br /> <br />
参考文献
Abou-Gharbia, Magid; Freed, Meier E.; McCaully, Ronald J.; Silver, Paul J.; Wendt, Robert L. Journal of Medicinal Chemistry, 1984 , vol. 27, # 12 p. 1743 - 1746
