hydrogen bromide in acetic acid 24 h; Ambient temperature;

N-bromosuccinmide in N,N-dimethyl-formamide T=0°C; 30 h;

bromine in acetic acid 1 h; Ambient temperatureother methoxy derivatives of ethyl indole-2-acrboxylate; pyridinium bromide perbromide or N-bromosuccinimide (NBS) as bromination agent; var. solvents, temperatures and reaction times; Product distributionMechanism;

bromine in acetic acid 0.00277778 h; 30 s, 24 h or 24 h with sodium acetate buffer; Product distribution;

1: hydrogen bromide / acetic acid / 24 h / Ambient temperature 2: 99.3 percent / aq. NaOH / ethanol; tetrahydrofuran / 1 h / Heating View Scheme