2-(2-(2-氨基-2-环己基乙酰氨基)-3,3-二甲基丁酰基)-八氢环戊并[c]吡咯-1-羧酸叔丁酯合成路线 （共 2 条）
反应条件
hydrogen; palladium(II) hydroxide/carbon in methanol; isopropanol acetate
T=20°C; P=1551.49 Torr; 2 h; Product distribution / selectivity;
参考文献
Tanoury, Gerald J.; Chen, Minzhang; Cochran, John E.
Patent: US2007/87973 A1, 2007 ;
Location in patent: Page/Page column 21; 47 ;
反应条件
1: 2-carboxypyrazine With 1,1'-carbonyldiimidazole in N,N-dimethyl-formamide
T=20 - 30°C; 1.5 h;
2: (1S,3aR,6aS)-tert-butyl 2-((S)-2-((S)-2-amino-2-cyclohexylacetamido)-3,3-dimethylbutanoyl)octahydrocyclopenta[c]pyrrole-1-carboxylate in N,N-dimethyl-formamide
T=15 - 30°C; 1 h;
3: With potassium carbonate in water; N,N-dimethyl-formamide
T=0°C; Product distribution / selectivity;
参考文献
Tanoury, Gerald J.; Chen, Minzhang; Cochran, John E.
Patent: US2007/87973 A1, 2007 ;
Location in patent: Page/Page column 21; 48 ;
