1: With potassium hydroxide; water 0.666667 h; Heating / reflux; 2: With hydrogenchloride; water T=20°C; pH=3 - 4;

in water; N,N-dimethyl-formamide

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.08 h / 20 °C 1.2: 20 °C 2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.33 h View Scheme

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.08 h / 20 °C 1.2: 20 °C 2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.33 h View Scheme

1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in acetone 12 h; Inert atmosphereReflux;