1-甲基-4-氧代-5-苯基哌啶-3-羧酸乙酯合成路线 （共 5 条）
反应条件
potassium tert-butylate in tetrahydrofuran
T=20°C; 2 h;
参考文献
BRISTOL-MYERS SQUIBB COMPANY; BOY, Kenneth M.; GUERNON, Jason M.; MACOR, John E.; OLSON, Richard E.; SHI, Jianliang; THOMPSON, Lorin A., III.; WU, Yong-Jin; XU, Li; ZHANG, Yunhui; ZUEV, Dmitry S.
Patent: WO2012/103297 A1, 2012 ;
Location in patent: Page/Page column 162 ;
反应条件
1: hydrogen; trifluoroacetic acid / palladium 10 on activated carbon / methanol / 20 °C / 3677.86 Torr
2: ethanol / 18 h / 20 °C
3: potassium carbonate / acetone / 2 h / 20 °C
4: potassium tert-butylate / tetrahydrofuran / 2 h / 20 °C
View Scheme
参考文献
BRISTOL-MYERS SQUIBB COMPANY; BOY, Kenneth M.; GUERNON, Jason M.; MACOR, John E.; OLSON, Richard E.; SHI, Jianliang; THOMPSON, III, Lorin A.; WU, Yong-Jin; XU, Li; ZHANG, Yunhui; ZUEV, Dmitry S.
Patent: WO2011/14535 A1, 2011 ;
WO 2011/014535 A1
反应条件
1.1: sodium hydride / tetrahydrofuran / 0.25 h / -10 °C
1.2: -10 - 40 °C
1.3: 0 °C
2.1: hydrogen; trifluoroacetic acid / palladium 10 on activated carbon / methanol / 20 °C / 3677.86 Torr
3.1: ethanol / 18 h / 20 °C
4.1: potassium carbonate / acetone / 2 h / 20 °C
5.1: potassium tert-butylate / tetrahydrofuran / 2 h / 20 °C
View Scheme
参考文献
BRISTOL-MYERS SQUIBB COMPANY; BOY, Kenneth M.; GUERNON, Jason M.; MACOR, John E.; OLSON, Richard E.; SHI, Jianliang; THOMPSON, III, Lorin A.; WU, Yong-Jin; XU, Li; ZHANG, Yunhui; ZUEV, Dmitry S.
Patent: WO2011/14535 A1, 2011 ;
WO 2011/014535 A1
反应条件
1: ethanol / 18 h / 20 °C
2: potassium carbonate / acetone / 2 h / 20 °C
3: potassium tert-butylate / tetrahydrofuran / 2 h / 20 °C
View Scheme
参考文献
BRISTOL-MYERS SQUIBB COMPANY; BOY, Kenneth M.; GUERNON, Jason M.; MACOR, John E.; OLSON, Richard E.; SHI, Jianliang; THOMPSON, III, Lorin A.; WU, Yong-Jin; XU, Li; ZHANG, Yunhui; ZUEV, Dmitry S.
Patent: WO2011/14535 A1, 2011 ;
WO 2011/014535 A1
反应条件
1: potassium carbonate / acetone / 2 h / 20 °C
2: potassium tert-butylate / tetrahydrofuran / 2 h / 20 °C
View Scheme
参考文献
BRISTOL-MYERS SQUIBB COMPANY; BOY, Kenneth M.; GUERNON, Jason M.; MACOR, John E.; OLSON, Richard E.; SHI, Jianliang; THOMPSON, III, Lorin A.; WU, Yong-Jin; XU, Li; ZHANG, Yunhui; ZUEV, Dmitry S.
Patent: WO2011/14535 A1, 2011 ;
WO 2011/014535 A1
