N-(3-(三氟甲基)-5-(4-甲基-1H-咪唑-1-基)苯基)-3-碘-4-甲基苯甲酰胺合成路线 （共 5 条）
反应条件
4-(N,N-dimethlyamino)pyridine; N-ethyl-N,N-diisopropylamine in tetrahydrofuran T=20°C; 2 h;
参考文献
Huang, Wei-Sheng; Shakespeare, William C.
Synthesis, 2007 , # 14 p. 2121 - 2124
反应条件
1: 3-Iodo-4-methyl-benzoic acid With thionyl chloride 1 h; Heating / reflux; 2: 5-(4-methyl-1H-imidazol-1-yl)-3-(trifluoromethyl)-benzeneamine With N-ethyl-N,N-diisopropylamine; 4-(N,N-dimethlyamino)pyridine in tetrahydrofuran; benzene T=20°C; 2 h;
参考文献
WO2007/21937 A2, ;
Page/Page column 38 ;
反应条件
4-(N,N-dimethlyamino)pyridine; N-ethyl-N,N-diisopropylamine in tetrahydrofuran; thionyl chloride; water
参考文献
Astar Biotech LLC; YU, Chunrong; Huang, Haihong; Zhang, Dongfeng; Li, Peng
Patent: US2014/31354 A1, 2014 ;
Location in patent: Paragraph 0293; 0396; 0397 ;
反应条件
1: N,N-dimethyl-formamide; thionyl chloride / 2 h / |Reflux 2: triethylamine / tetrahydrofuran / 1 h / 20 °C View Scheme
反应条件
caesium carbonate; tris(dibenzylideneacetone)dipalladium (0); 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene in 1,4-dioxane; tert-butyl alcohol T=100°C; 7 h;
参考文献
Synthesis, , # 14 p. 2121 - 2124
