3-氨基呋喃并2,3-c吡啶-2-羧酸乙酯合成路线 （共 3 条）
反应条件
1: With trifluoroacetic acid in dichloromethane
T=0 - 20°C;
2: With hydrogenchloride; water in dichloromethane
3: With sodium hydroxide; sodium hydrogencarbonate in water; ethyl acetate
pH=~ 7; Product distribution / selectivity;
参考文献
Miknis, Greg; Lyssikatos, Joseph P.; Laird, Ellen; Tarlton, Eugene; Buckmelter, Alexandre J.; Ren, Li; Rast, Bryson; Schlacter, Stephen T.; Wenglowsky, Steven Mark
Patent: US2007/49603 A1, 2007 ;
Location in patent: Page/Page column 60 ;
US 20070049603 A1
反应条件
potassium carbonate in ethanol
T=150°C; 0.5 h; microwave irradiation;
参考文献
Cailly, Thomas; Lemaitre, Stephane; Fabis, Frederic; Rault, Sylvain
Synthesis, 2007 , # 20 p. 3247 - 3251
反应条件
1: 3-bromoisonicotinonitrile With sodium hydride in N,N-dimethyl-formamide
T=0°C;
2: oxyacetic acid ethyl ester in N,N-dimethyl-formamide
T=20°C; 1 h; Product distribution / selectivity;
参考文献
Miknis, Greg; Lyssikatos, Joseph P.; Laird, Ellen; Tarlton, Eugene; Buckmelter, Alexandre J.; Ren, Li; Rast, Bryson; Schlacter, Stephen T.; Wenglowsky, Steven Mark
Patent: US2007/49603 A1, 2007 ;
Location in patent: Page/Page column 49 ;
US 20070049603 A1
