(+/-) 3-乙基-3-(4-吡啶)-2,6-哌啶二酮合成路线 （共 6 条）
反应条件
caesium carbonate in acetonitrile 0.5 h; Heating;
参考文献
Leung; Rowlands; Jarman; Foster; Griggs; Wilman
Journal of Medicinal Chemistry, 1987 , vol. 30, # 9 p. 1550 - 1554
反应条件
potassium tert-butylate in tert-butyl alcohol
T=25°C;
参考文献
National Research Development Corporation
Patent: US5112976 A1, 1992 ;
反应条件
2: acetic acid, H2SO4, HCl / 3.5 h / Heating
View Scheme
参考文献
Foster, Allan B.; Jarman, Michael; Leung, Chui-Sheung; Rowlands, Martin G.; Taylor, Grahame N.; et al.
Journal of Medicinal Chemistry, 1985 , vol. 28, # 2 p. 200 - 204
反应条件
1: 87 percent / 40percent w/w Triton B / 2-methyl-propan-2-ol; methanol / 48 h / Ambient temperature
2: 1.) lithium diisopropylamide / 1.) THF, -78 deg C; 2.) allowed to r.t. during 1 h
3: 300 mg / glacial acetic acid, conc. sulphuric acid / 2 h / 100 °C
4: 66 percent / potassium tert-butoxide / tetrahydrofuran / 2 h / Ambient temperature
View Scheme
参考文献
Boss, Aileen M.; Clissold, Derek W.; Mann, John; Markson, Andrew J.; Thickitt, Christopher P.
Tetrahedron, 1989 , vol. 45, # 18 p. 6011 - 6017
反应条件
1: 1.) lithium diisopropylamide / 1.) THF, -78 deg C; 2.) allowed to r.t. during 1 h
2: 300 mg / glacial acetic acid, conc. sulphuric acid / 2 h / 100 °C
3: 66 percent / potassium tert-butoxide / tetrahydrofuran / 2 h / Ambient temperature
View Scheme
参考文献
Boss, Aileen M.; Clissold, Derek W.; Mann, John; Markson, Andrew J.; Thickitt, Christopher P.
Tetrahedron, 1989 , vol. 45, # 18 p. 6011 - 6017
反应条件
1: 300 mg / glacial acetic acid, conc. sulphuric acid / 2 h / 100 °C
2: 66 percent / potassium tert-butoxide / tetrahydrofuran / 2 h / Ambient temperature
View Scheme
参考文献
Boss, Aileen M.; Clissold, Derek W.; Mann, John; Markson, Andrew J.; Thickitt, Christopher P.
Tetrahedron, 1989 , vol. 45, # 18 p. 6011 - 6017
