N-甲基-2-硝基-4-[[2-[5-(三氟甲基)-1H-咪唑-2-基]-4-吡啶基]氧基]-苯胺合成路线 （共 4 条）
反应条件
1: 4-(4-Methylamino-3-nitro-phenoxy)-pyridine-2-carbonitrile With sodium methylate in isopropyl alcohol
T=50°C; 1 h;
2: 3-bromo-1,1,1-trifluoroacetone With ammonium acetate in isopropyl alcohol
T=70 - 85°C; 21 h; Product distribution / selectivity;
参考文献
Novartis AG
Patent: US2007/49622 A1, 2007 ;
Location in patent: Page/Page column 42 ;
反应条件
ammonia in methanol; water
T=20°C;
参考文献
NOVARTIS AG
Patent: WO2008/11154 A2, 2008 ;
Location in patent: Page/Page column 28 ;
反应条件
ammonia in methanol; water
T=20°C; Product distribution / selectivity;
参考文献
Novartis AG
Patent: US2007/49622 A1, 2007 ;
Location in patent: Page/Page column 19 ;
反应条件
ammonia in ethanol; water; ethyl acetate
Product distribution / selectivity;
参考文献
NOVARTIS AG
Patent: WO2008/140850 A1, 2008 ;
Location in patent: Page/Page column 60 ;
WO 2008/140850 A1
