RAF 265; 1-甲基-5-[[2-[5-(三氟甲基)-1H-咪唑-2-基]-4-吡啶基]氧基]-N-[4-(三氟甲基)苯基]-1H-苯并咪唑-2-胺合成路线 （共 2 条）
反应条件
1: in acetonitrile T=20°C; 0.333333 h; 2: With 2-chloro-1-methyl-pyridinium iodide; triethylamine in acetonitrile T=50°C; 5 h; Product distribution / selectivity;
参考文献
Novartis AG
Patent: US2007/49622 A1, 2007 ;
Location in patent: Page/Page column 41 ;
反应条件
1: 4-[1-methyl-2-(4-(trifluoromethyl)phenylamino)-1H-benzoimidazol-5-yloxy]-pyridine-2-carbonitrile With sodium methylate in isopropyl alcohol T=50°C; 1 h; 2: 3-bromo-1,1,1-trifluoroacetone With ammonium acetate in isopropyl alcohol T=70 - 85°C; 23 h; Product distribution / selectivity;
参考文献
Novartis AG
Patent: US2007/49622 A1, 2007 ;
Location in patent: Page/Page column 44 ;
