1: sodium acetate / water; methanol / 3 h / 45 °C 2: sodium hydroxide / methanol / 24 h / 40 - 50 °C / |Inert atmosphere 3: 2-chloro-4,6-dimethoxy-[1,3,5]triazine; 4-methyl-morpholine / N,N-dimethyl-formamide / 6 h / 20 °C View Scheme

1: sodium acetate / water; methanol / 3 h / 45 °C 2: sodium hydroxide / methanol / 24 h / 40 - 50 °C / |Inert atmosphere View Scheme

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1098214', constants.ctx, '0')">hydrogenchloride</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '156815', constants.ctx, '0')">5,5-dibromomeldrum's acid</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1696894', constants.ctx, '0')">diethyl ether</a> <br />T=20&deg;C;&nbsp;24&nbsp;h;&nbsp;<br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1: lithium chloride; anhydrous lithium acetate; tetrabutyl-ammonium chloride; palladium diacetate / N,N-dimethyl-formamide / 3 h / 70 &deg;C<br />2: 5,5-dibromomeldrum's acid; hydrogenchloride / diethyl ether / 24 h / 20 &deg;C<br /> <br /> &nbsp;