6-硝基-1(2H)-异喹啉酮合成路线 （共 4 条）
反应条件
ammonia in ethylene glycol
T=140°C; 0.5 h; Microwave irradiation;
参考文献
BRISTOL-MYERS SQUIBB COMPANY; ZHANG, Xiaojun; GLUNZ, Peter W.; PRIESTLEY, Eldon Scott; JOHNSON, James, A.; WURTZ, Nicholas, Ronald; LADZIATA, Vladimir
Patent: WO2013/184734 A1, 2013 ;
Location in patent: Paragraph 00148; 00149 ;
反应条件
1: dichloromethane / 0.5 h / 0 °C
2: N,N-dimethyl-formamide / 3 h / 143 °C
3: ammonia / ethylene glycol / 0.5 h / 140 °C / |Microwave irradiation
View Scheme
参考文献
BRISTOL-MYERS SQUIBB COMPANY; ZHANG, Xiaojun; GLUNZ, Peter W.; PRIESTLEY, Eldon Scott; JOHNSON, James, A.; WURTZ, Nicholas, Ronald; LADZIATA, Vladimir
Patent: WO2013/184734 A1, 2013 ;
反应条件
1: N,N-dimethyl-formamide / 3 h / 143 °C
2: ammonia / ethylene glycol / 0.5 h / 140 °C / |Microwave irradiation
View Scheme
参考文献
BRISTOL-MYERS SQUIBB COMPANY; ZHANG, Xiaojun; GLUNZ, Peter W.; PRIESTLEY, Eldon Scott; JOHNSON, James, A.; WURTZ, Nicholas, Ronald; LADZIATA, Vladimir
Patent: WO2013/184734 A1, 2013 ;
反应条件
1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 2 h / 20 - 40 °C
2: dichloromethane / 0.5 h / 0 °C
3: N,N-dimethyl-formamide / 3 h / 143 °C
4: ammonia / ethylene glycol / 0.5 h / 140 °C / |Microwave irradiation
View Scheme
参考文献
BRISTOL-MYERS SQUIBB COMPANY; ZHANG, Xiaojun; GLUNZ, Peter W.; PRIESTLEY, Eldon Scott; JOHNSON, James, A.; WURTZ, Nicholas, Ronald; LADZIATA, Vladimir
Patent: WO2013/184734 A1, 2013 ;
