6-氨基-2,3-二氢-苯并[1,4]噁嗪-4-羧酸叔丁酯合成路线 （共 4 条）
反应条件
hydrogen; Raney Ni in ethanol
P=2068.65 Torr;
参考文献
Schering Corporation and Pharmacopeia Drug Discovery, Inc.
Patent: US2007/93477 A1, 2007 ;
Location in patent: Page/Page column 43 ;
反应条件
1.1: sodium hydrogencarbonate / water / 0.5 h / 0 °C
1.2: |Reflux
2.1: borane-THF / tetrahydrofuran / 2 h / |Reflux
2.2: 1 h / |Reflux
3.1: sodium hydrogencarbonate / dichloromethane / 0.5 h / 0 °C
3.2: 2 h / 20 °C
4.1: palladium 10 on activated carbon; hydrogen / methanol; tetrahydrofuran / 2 h / 20 °C
View Scheme
参考文献
Lee, Jeewoo; Tran, Phuong-Thao; Hoang, Van-Hai; Thorat, Shivaji A.; Kim, Sung Eun; Ann, Jihyae; Chang, Yu Jin; Nam, Dong Woo; Song, Hyundong; Mook-Jung, Inhee; Lee, Jiyoun
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 13 p. 3821 - 3830
反应条件
1.1: borane-THF / tetrahydrofuran / 2 h / |Reflux
1.2: 1 h / |Reflux
2.1: sodium hydrogencarbonate / dichloromethane / 0.5 h / 0 °C
2.2: 2 h / 20 °C
3.1: palladium 10 on activated carbon; hydrogen / methanol; tetrahydrofuran / 2 h / 20 °C
View Scheme
参考文献
Lee, Jeewoo; Tran, Phuong-Thao; Hoang, Van-Hai; Thorat, Shivaji A.; Kim, Sung Eun; Ann, Jihyae; Chang, Yu Jin; Nam, Dong Woo; Song, Hyundong; Mook-Jung, Inhee; Lee, Jiyoun
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 13 p. 3821 - 3830
反应条件
1.1: sodium hydrogencarbonate / dichloromethane / 0.5 h / 0 °C
1.2: 2 h / 20 °C
2.1: palladium 10 on activated carbon; hydrogen / methanol; tetrahydrofuran / 2 h / 20 °C
View Scheme
参考文献
Lee, Jeewoo; Tran, Phuong-Thao; Hoang, Van-Hai; Thorat, Shivaji A.; Kim, Sung Eun; Ann, Jihyae; Chang, Yu Jin; Nam, Dong Woo; Song, Hyundong; Mook-Jung, Inhee; Lee, Jiyoun
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 13 p. 3821 - 3830
