1.1: dichloromethane; acetonitrile / 30 h / 20 °C 1.2: 1 h / 80 °C 2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C 2.2: 2 h / -78 °C 3.1: hydrogenchloride / tetrahydrofuran; 1,4-dioxane / 1 h / 0 - 20 °C 4.1: triethylamine / dichloromethane / 0 °C 5.1: triethylamine; potassium carbonate; sodium iodide / acetonitrile / 35 h / 80 °C 6.1: lithium hydroxide hydrate / tetrahydrofuran; ethanol / 1.5 h / 20 °C 7.1: ethanol / 3 h / 80 °C / |Sealed tube 8.1: |Resolution of racemate View Scheme

1.1: N-bromosuccinmide; dibenzoyl peroxide / tetrachloromethane / 2.5 h / |Reflux 2.1: dichloromethane; acetonitrile / 30 h / 20 °C 2.2: 1 h / 80 °C 3.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C 3.2: 2 h / -78 °C 4.1: hydrogenchloride / tetrahydrofuran; 1,4-dioxane / 1 h / 0 - 20 °C 5.1: triethylamine / dichloromethane / 0 °C 6.1: triethylamine; potassium carbonate; sodium iodide / acetonitrile / 35 h / 80 °C 7.1: lithium hydroxide hydrate / tetrahydrofuran; ethanol / 1.5 h / 20 °C 8.1: ethanol / 3 h / 80 °C / |Sealed tube 9.1: |Resolution of racemate View Scheme

1.1: borane-THF / tetrahydrofuran / 0.5 h / 0 - 20 °C 1.2: 2 h / 90 °C 2.1: 1H-imidazole / dichloromethane / 20 °C 3.1: dichloromethane; acetonitrile / 30 h / 20 °C 3.2: 1 h / 80 °C 4.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C 4.2: 2 h / -78 °C 5.1: hydrogenchloride / tetrahydrofuran; 1,4-dioxane / 1 h / 0 - 20 °C 6.1: triethylamine / dichloromethane / 0 °C 7.1: triethylamine; potassium carbonate; sodium iodide / acetonitrile / 35 h / 80 °C 8.1: lithium hydroxide hydrate / tetrahydrofuran; ethanol / 1.5 h / 20 °C 9.1: ethanol / 3 h / 80 °C / |Sealed tube 10.1: |Resolution of racemate View Scheme

1.1: dichloromethane; acetonitrile / 30 h / 20 °C 1.2: 1 h / 80 °C 2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C 2.2: 2 h / -78 °C 3.1: hydrogenchloride / tetrahydrofuran; 1,4-dioxane / 1 h / 0 - 20 °C 4.1: triethylamine / dichloromethane / 0 °C 5.1: triethylamine; potassium carbonate; sodium iodide / acetonitrile / 35 h / 80 °C 6.1: lithium hydroxide hydrate / tetrahydrofuran; ethanol / 1.5 h / 20 °C 7.1: ethanol / 3 h / 80 °C / |Sealed tube 8.1: |Resolution of racemate View Scheme

1: triethylamine / dichloromethane / 0 °C 2: triethylamine; potassium carbonate; sodium iodide / acetonitrile / 35 h / 80 °C 3: lithium hydroxide hydrate / tetrahydrofuran; ethanol / 1.5 h / 20 °C 4: ethanol / 3 h / 80 °C / |Sealed tube 5: |Resolution of racemate View Scheme

1: triethylamine; potassium carbonate; sodium iodide / acetonitrile / 35 h / 80 °C 2: lithium hydroxide hydrate / tetrahydrofuran; ethanol / 1.5 h / 20 °C 3: ethanol / 3 h / 80 °C / |Sealed tube 4: |Resolution of racemate View Scheme

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C 1.2: 2 h / -78 °C 2.1: hydrogenchloride / tetrahydrofuran; 1,4-dioxane / 1 h / 0 - 20 °C 3.1: triethylamine / dichloromethane / 0 °C 4.1: triethylamine; potassium carbonate; sodium iodide / acetonitrile / 35 h / 80 °C 5.1: lithium hydroxide hydrate / tetrahydrofuran; ethanol / 1.5 h / 20 °C 6.1: ethanol / 3 h / 80 °C / |Sealed tube 7.1: |Resolution of racemate View Scheme

1: hydrogenchloride / tetrahydrofuran; 1,4-dioxane / 1 h / 0 - 20 °C 2: triethylamine / dichloromethane / 0 °C 3: triethylamine; potassium carbonate; sodium iodide / acetonitrile / 35 h / 80 °C 4: lithium hydroxide hydrate / tetrahydrofuran; ethanol / 1.5 h / 20 °C 5: ethanol / 3 h / 80 °C / |Sealed tube 6: |Resolution of racemate View Scheme

1: lithium hydroxide hydrate / tetrahydrofuran; ethanol / 1.5 h / 20 °C 2: ethanol / 3 h / 80 °C / |Sealed tube 3: |Resolution of racemate View Scheme