1: 3-bromo-5-pyridine-carboxylic acid With tetrakis(triphenylphosphine) palladium(0) in ethylene glycol dimethyl ether T=20°C; 0.25 h; 2: [4-(hydroxymethyl)-phenyl]-boronic acid With sodium carbonate in ethylene glycol dimethyl ether; water T=95°C; 21 h; Heating / reflux; 3: With hydrogenchloride in ethylene glycol dimethyl ether; water pH=3;