2,2'-bis-(diphenylphosphino)-1,1'- binaphthyl; sodium t-butanolate; palladium diacetate in toluene T=100°C; 24 h;

1: 70.6 percent / 1.) Toluene sulfonic acid (cat. amount) / 1.) reflux, 5 h 2.) 25 deg C, 7 h 2: 64.8 percent / acetonitrile; CH2Cl2 / 12 h / Ambient temperature 3: 69 percent / aq. EtOH / tetrahydrofuran / 11 h / Ambient temperature 4: 49 percent / 2,6-Lutidine / CH2Cl2 / 0.25 h / ice bath 5: 62 percent / tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / Ambient temperature 6: 65 percent / 1.) LiAlH4 / diethyl ether / 1.) CO2/isopropyl alcohol bath, 10 min 2.) room temperature, 10 min View Scheme