1: 49 percent / 2,6-Lutidine / CH2Cl2 / 0.25 h / ice bath 2: 62 percent / tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / Ambient temperature 3: 65 percent / 1.) LiAlH4 / diethyl ether / 1.) CO2/isopropyl alcohol bath, 10 min 2.) room temperature, 10 min View Scheme

<b>Multi-step reaction with 2 steps<br /> </b>1: 64.8 percent / acetonitrile; CH₂Cl₂ / 12 h / Ambient temperature<br />2: 69 percent / aq. EtOH / tetrahydrofuran / 11 h / Ambient temperature<br /> <br /> &nbsp;

<b>Multi-step reaction with 4 steps<br /> </b>1: 76 percent / 2,6-Lutidine / CH₂Cl₂ / 0.5 h / 0 &deg;C<br />2: 70.6 percent / 1.) Toluene sulfonic acid (cat. amount) / 1.) reflux, 5 h 2.) 25 deg C, 7 h<br />3: 64.8 percent / acetonitrile; CH₂Cl₂ / 12 h / Ambient temperature<br />4: 69 percent / aq. EtOH / tetrahydrofuran / 11 h / Ambient temperature<br /> <br /> &nbsp;