2-溴-1-(3-氟苯基)丙酮合成路线 （共 2 条）
反应条件
bromine in dichloromethane
T=20°C; Inert atmosphere;
参考文献
RESEARCH TRIANGLE INSTITUTE; CARROLL, Frank Ivy; BLOUGH, Bruce; ABRAHAM, Philip
Patent: WO2010/121022 A1, 2010 ;
Location in patent: Page/Page column 63-64 ;
WO 2010/121022 A1
反应条件
1: AlCl3, aluminium chloride / dichloromethane / 0 - 70 °C
2: copper(ll) bromide / chloroform; ethyl acetate / 4 h / Reflux
View Scheme
参考文献
Zheng, Yong-Yong; Guo, Lin; Zhen, Xue-Chu; Li, Jian-Qi
European Journal of Medicinal Chemistry, 2012 , vol. 54, p. 123 - 136
