8-苄氧基-1,4-二噁螺[4.5]癸烷合成路线 （共 6 条）
反应条件
ammonium cerium(IV) nitrate in water; acetonitrile T=70°C; 0.0333333 h;
参考文献
Ates, Ali; Gautier, Arnaud; Leroy, Bernard; Plancher, Jean-Marc; Quesnel, Yannick; Vanherck, Jean-Christophe; Marko, Istvan E.
Tetrahedron, 2003 , vol. 59, # 45 p. 8989 - 8999
反应条件
1: 1,4-dioxaspiro[4.5]-decan-8-ol With sodium hydride in tetrahydrofuran
T=0°C; 1.5 h;
2: benzyl bromide in tetrahydrofuran
T=0 - 20°C;
参考文献
Emory University
Patent: US2006/292073 A1, 2006 ;
Location in patent: Page/Page column 12 ;
反应条件
tetra-(n-butyl)ammonium iodide in hexane; ethyl acetate; N,N-dimethyl-formamide
参考文献
Emory University
Patent: US5817776 A1, 1998 ;
反应条件
1.1: NaBH4 / methanol / 3 h / 0 °C
2.1: KH / tetrahydrofuran / 0 - 20 °C
2.2: 83 percent / tetrahydrofuran / 20 °C
View Scheme
参考文献
Spino, Claude; Hill, Bryan; Dube, Pascal; Gingras, Stephane
Canadian Journal of Chemistry, 2003 , vol. 81, # 1 p. 81 - 108
反应条件
1: 90 percent / TosOH / benzene / Heating
2: 93 percent / NaH / tetrahydrofuran / Heating
View Scheme
参考文献
Hwu; Leopold
Journal of the Chemical Society - Series Chemical Communications, 1984 , vol. NO. 11, p. 721 - 723
反应条件
1: 75 percent / 2 M aq. H2SO4 / acetone / Heating
2: 98 percent / HCl / ethanol / Heating
3: 85 percent / diethyl ether / Ambient temperature
4: DBU / tetrahydrofuran / 4 h / -5 °C
5: diethyl ether / -78 °C
View Scheme
参考文献
Hwu; Leopold
Journal of the Chemical Society - Series Chemical Communications, 1984 , vol. NO. 11, p. 721 - 723
