(±)-二氢-4-[[3-甲氧基-4-(苯基甲氧基)苯基]甲基]-2(3H)-呋喃酮合成路线 （共 12 条）
反应条件
1: With lithium borohydride in tetrahydrofuran
5.5 h; Heating;
2: With hydrogenchloride in tetrahydrofuran
T=20°C; 15 h; Further stages.;
参考文献
Takemoto, Masumi; Hongo, Yoko; Aoshima, Youichi; Kutney, James Peter
Heterocycles, 2006 , vol. 69, # 1 p. 429 - 436
反应条件
jones reagent in water
sonification;
参考文献
Srikrishna; Danieldoss
Synthetic Communications, 2001 , vol. 31, # 15 p. 2357 - 2364
反应条件
1.1: sodium methoxide / methanol / 5.5 h / Heating
1.2: 78 percent / aq. HCl / H2O / 0 °C
2.1: 90 percent / Mg / methanol / 5.5 h / 0 °C
3.1: LiBH4 / tetrahydrofuran / 5.5 h / Heating
3.2: 48 percent / aq. HCl / tetrahydrofuran / 15 h / 20 °C
View Scheme
参考文献
Takemoto, Masumi; Hongo, Yoko; Aoshima, Youichi; Kutney, James Peter
Heterocycles, 2006 , vol. 69, # 1 p. 429 - 436
反应条件
potassium carbonate; sodium iodide in acetone
15 h; Heating;
参考文献
Loriot; Thomas; Brown
Bulletin de la Societe Chimique de France, 1985 , vol. NO. 5, p. 871 - 875
反应条件
1.1: 90 percent / Mg / methanol / 5.5 h / 0 °C
2.1: LiBH4 / tetrahydrofuran / 5.5 h / Heating
2.2: 48 percent / aq. HCl / tetrahydrofuran / 15 h / 20 °C
View Scheme
参考文献
Takemoto, Masumi; Hongo, Yoko; Aoshima, Youichi; Kutney, James Peter
Heterocycles, 2006 , vol. 69, # 1 p. 429 - 436
反应条件
1: 81 percent / N-bromosuccinimide / CH2Cl2
2: 85 percent / sodium cyanoborohydride; tri-n-butyltin chloride / AIBN / 2-methyl-propan-2-ol / Heating
3: 79 percent / Jones reagent / H2O / sonification
View Scheme
参考文献
Srikrishna; Danieldoss
Synthetic Communications, 2001 , vol. 31, # 15 p. 2357 - 2364
反应条件
1: lithium aluminum hydride / diethyl ether
2: 81 percent / N-bromosuccinimide / CH2Cl2
3: 85 percent / sodium cyanoborohydride; tri-n-butyltin chloride / AIBN / 2-methyl-propan-2-ol / Heating
4: 79 percent / Jones reagent / H2O / sonification
View Scheme
参考文献
Srikrishna; Danieldoss
Synthetic Communications, 2001 , vol. 31, # 15 p. 2357 - 2364
反应条件
1: 85 percent / sodium cyanoborohydride; tri-n-butyltin chloride / AIBN / 2-methyl-propan-2-ol / Heating
2: 79 percent / Jones reagent / H2O / sonification
View Scheme
参考文献
Srikrishna; Danieldoss
Synthetic Communications, 2001 , vol. 31, # 15 p. 2357 - 2364
反应条件
1: 77.6 percent / H2 / Pd/C (10percent) / ethyl acetate / 7 h / 3750.3 Torr / Ambient temperature
2: 93.6 percent / carbonate de potassium, iodure de sodium / acetone / 15 h / Heating
View Scheme
参考文献
Loriot; Thomas; Brown
Bulletin de la Societe Chimique de France, 1985 , vol. NO. 5, p. 871 - 875
反应条件
1.1: 90 percent / NaI; K2CO3 / methanol
2.1: sodium methoxide / methanol / 5.5 h / Heating
2.2: 78 percent / aq. HCl / H2O / 0 °C
3.1: 90 percent / Mg / methanol / 5.5 h / 0 °C
4.1: LiBH4 / tetrahydrofuran / 5.5 h / Heating
4.2: 48 percent / aq. HCl / tetrahydrofuran / 15 h / 20 °C
View Scheme
参考文献
Takemoto, Masumi; Hongo, Yoko; Aoshima, Youichi; Kutney, James Peter
Heterocycles, 2006 , vol. 69, # 1 p. 429 - 436
