sodium hydride in tetrahydrofuran T=0 - 20°C; 26 h; Heating / reflux;

potassium hydroxide; iodine in diethyl ether; dimethyl sulfoxide addn. of NCCH2COOC2H5 to mixt. of Cr(CO)3-complex/powd. KOH in DMSO (stirring), warming (45°C, 2.5 h), diln. with aq. HCl, extn. with Et2O, treating with excess I2 (room temp., 3 h); distn. (reduced pressure);

potassium hydroxide; iodine 1.) DMSO, 45 deg C, 2.5 h, 2.) Et2O, 25 deg C, 3 h; Yield given. Multistep reaction;

1: (i) Br2, (irradiation), (ii) /BRN= 4652394/, aq. EtOH 2: (i) NaH, Et2O, (ii) /BRN= 956591/ View Scheme

hydrogenchloride