1-(5-溴-2-吡啶基)-2-吡咯烷酮合成路线 （共 5 条）
反应条件
potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct in dimethyl sulfoxide T=80°C; Inert atmosphere;
参考文献
Gordeev, Mikhail Fedorovich; Yuan, Zhengyu; Liu, Jinqian; Wang, Qiang
Patent: US2010/69441 A1, 2010 ;
Location in patent: Page/Page column 36-37 ;
反应条件
potassium carbonate in acetonitrile
T=20°C; Inert atmosphere;
参考文献
EUROSCREEN S.A.; HOVEYDA, Hamid; DUTHEUIL, Guillaume; EL BOUSMAQUI, Mohamed; BERNARD, Jerome
Patent: WO2011/151434 A1, 2011 ;
Location in patent: Page/Page column 53 ;
WO 2011/151434 A1
反应条件
caesium carbonate; ethyl 2-oxo-cyclohexanecarboxylate; copper(I) bromide in dimethyl sulfoxide
T=90°C; Inert atmosphere;
参考文献
Gordeev, Mikhail Fedorovich; Yuan, Zhengyu; Liu, Jinqian; Wang, Qiang
Patent: US2010/69441 A1, 2010 ;
Location in patent: Page/Page column 36 ;
反应条件
sodium tetrahydroborate in tetrahydrofuran; water
参考文献
Gleave, Robert J.; Beswick, Paul J.; Brown, Andrew J.; Giblin, Gerard M.P.; Haslam, Carl P.; Livermore, David; Moses, Andrew; Nicholson, Neville H.; Page, Lee W.; Slingsby, Brian; Swarbrick, Martin E.
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 23 p. 6578 - 6581
反应条件
1: pyrrolidin-2-one With sodium hydride in N,N-dimethyl-formamide
T=0 - 20°C; 0.5 h;
2: 5-Bromo-2-chloropyridine in N,N-dimethyl-formamide
T=20 - 80°C; 20.5 h; Product distribution / selectivity;
参考文献
GLAXO GROUP LIMITED
Patent: WO2007/25596 A1, 2007 ;
Location in patent: Page/Page column 30 ;
WO 2007/025596 A1
