3-(2,2-二甲基-1,3-二氧戊环-4-基)-2,2-二氟-3-羟基丙酸乙酯合成路线 （共 7 条）
反应条件
silica gel in hexane; dichloromethane; ethyl acetate Resolution of racemate;
参考文献
Pharmaessentia Corp.
Patent: EP2508528 A1, 2012 ;
Location in patent: Page/Page column 8 ;
反应条件
4-(N,N-dimethlyamino)pyridine in toluene T=80 - 90°C; 6 h;
参考文献
CHEMAGIS LTD.; PERRIGO COMPANY
Patent: WO2007/70804 A2, 2007 ;
Location in patent: Page/Page column 20-21 ;
反应条件
4-(N,N-dimethlyamino)pyridine in ethyl acetate T=65 - 70°C; 4 h;
参考文献
Chemagis Ltd.
Patent: US2007/249823 A1, 2007 ;
Location in patent: Page/Page column 10; 11 ;
反应条件
1: ethyl (3RS)-2,2-difluoro-3-(2,2-dimethyldioxolan-4-yl)propionate With water; pyridinium trifluoroacetate in water; acetonitrile 3 h; Heating / reflux; 2: benzoyl chloride With pyridine; 4-(N,N-dimethlyamino)pyridine in ethyl acetate T=0 - 65°C; 10 h; Product distribution / selectivity;
参考文献
WO2007/49295 A2, ;
Page/Page column 13; 15-16 ;
反应条件
zinc in tetrahydrofuran; diethyl ether
参考文献
Chou; Heath; Patterson; Poteet; Lakin; Hunt
Synthesis, 1992 , # 6 p. 565 - 570
反应条件
4-(N,N-dimethlyamino)pyridine in toluene
T=80 - 90°C; 6 h;
参考文献
CHEMAGIS LTD.; PERRIGO COMPANY
Patent: WO2007/70804 A2, 2007 ;
Location in patent: Page/Page column 21-22 ;
反应条件
4-(N,N-dimethlyamino)pyridine in toluene
T=80°C; 6 h;
参考文献
CHEMAGIS LTD.; PERRIGO COMPANY
Patent: WO2007/70804 A2, 2007 ;
Location in patent: Page/Page column 23-24 ;
