1,8-二氨基-3,6-二氧杂辛烷合成路线 （共 65 条）
反应条件
sodium methylate in methanol T=20°C; Acylation; Cyclization; 8 h;
参考文献
Lipkowski; Urbanczyk-Lipkowska; Jurczak
Polish Journal of Chemistry, 2002 , vol. 76, # 5 p. 729 - 736
反应条件
in methanol T=25°C; P=750.06 Torr; 168 h;
参考文献
Jurczak, Janusz; Kasprzyk, Stanislaw; Salanski, Piotr; Stankiewicz, Tomasz
Journal of the Chemical Society, Chemical Communications, 1991 , # 14 p. 956 - 957
反应条件
in toluene 1.)0 deg C, 7 h 2.)overnight;
参考文献
Gansow, Otto A.; Kausar, A. Rashid; Triplett, Kelly B.
Journal of Heterocyclic Chemistry, 1981 , vol. 18, p. 297 - 302
反应条件
triethylamine in methanol T=35°C; 24 h;
参考文献
Bioconjugate Chemistry, , vol. 22, # 10 p. 2186 - 2197
反应条件
in dichloromethane T=0 - 20°C;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 17, # 15 p. 4208 - 4212
反应条件
hydrogenchloride in 1,4-dioxane T=0 - 20°C; 1.5 h;
参考文献
Journal of the American Chemical Society, , vol. 118, # 16 p. 3789 - 3800
反应条件
sodium hydroxide in dichloromethane
参考文献
Tetrahedron Letters, , vol. 49, # 41 p. 6003 - 6006
反应条件
1: 54 percent / methanol / -78 - 20 °C 2: 97 percent / tetrahydrofuran / 3 h / 20 °C 3: 97 percent / aq. NH4OH / methanol / 24 h / Heating View Scheme
参考文献
Phytochemistry, , vol. 63, # 3 p. 315 - 334
反应条件
sodium azide; CuSO4‵5H2O; trifluoromethylsulfonic anhydride; potassium carbonate in methanol; dichloromethane; water T=20°C;
参考文献
Li, Ying; Schaffer, Paul; Perrin, David M.
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 23 p. 6313 - 6316
