2,5-二甲基-1,3-恶唑-4-甲醛合成路线 （共 3 条）
反应条件
diisobutylaluminium hydride in dichloromethane; toluene T=-78°C; 0.0833333 h;
参考文献
Journal of Medicinal Chemistry, , vol. 50, # 10 p. 2399 - 2407
反应条件
manganese(IV) oxide in chloroform 21 h; Ambient temperature;
参考文献
Kukla, Michael J.; Fortunato, James M.
Journal of Organic Chemistry, 1984 , vol. 49, # 25 p. 5003 - 5006
反应条件
1: With titanium(IV) isopropylate in methanol
T=0°C; 3 h; Inert atmosphere;
2: With sodium tetrahydroborate in methanol
T=0 - 20°C;
参考文献
COMENTIS, INC.; ASTELLAS PHARMA INC.; BILCER, Geoffrey, M.; DEVASAMUDRAM, Thippeswamy; LILLY, John, C.; ANKALA, Sudha, V.; MOSKALEV, Nikolai, V.; LIU, Chunfeng; INOUE, Makoto; KAWAKAMI, Shimpei; MUNAKATA, Ryosuke; HAMAJIMA, Toshihiro
Patent: WO2012/54510 A1, 2012 ;
Location in patent: Page/Page column 88 ;
WO 2012/054510 A1
