(2,5-二甲基-1,3-噁唑-4-基)甲醇合成路线 (共 5 条)
反应条件
1: SOCl2 / benzene / 1.5 h / 23 - 30 °C 2: LiAlH4 View Scheme
参考文献
Journal of the American Chemical Society, , vol. 128, # 16 p. 5310 - 5311
反应条件
1: 4-hydroxymethyl-2-methyloxazole With n-butyllithium; lithium diethylamide in tetrahydrofuran; hexane T=-78°C; 2: methyl trifluoromethanesulfonate in tetrahydrofuran; hexane T=-78°C; Further stages.;
参考文献
Organic Letters, , vol. 1, # 1 p. 87 - 90
反应条件
lithium aluminium tetrahydride
参考文献
Journal of the American Chemical Society, , vol. 128, # 16 p. 5310 - 5311
反应条件
manganese(IV) oxide in chloroform 21 h; Ambient temperature;
参考文献
Kukla, Michael J.; Fortunato, James M.
Journal of Organic Chemistry, 1984 , vol. 49, # 25 p. 5003 - 5006
反应条件
1.1: 77 percent / diphenylphosphoryl azide; DBU / toluene / 17 h / 20 °C 2.1: PPh3 / tetrahydrofuran / 7 h / 20 °C 2.2: 52 mg / H2O / tetrahydrofuran / 55 °C View Scheme
参考文献
Ghosh, Arun K.; Kumaragurubaran, Nagaswamy; Hong, Lin; Kulkarni, Sarang S.; Xu, Xiaoming; Chang, Wanpin; Weerasena, Vajira; Turner, Robert; Koelsch, Gerald; Bilcer, Geoffrey; Tang, Jordan
Journal of Medicinal Chemistry, 2007 , vol. 50, # 10 p. 2399 - 2407