(R)-5-氨基-3-(1-(2-(三氟甲基)苯基)乙氧基)噻吩-2-羧酸甲酯合成路线 （共 2 条）
反应条件
1: With iron; acetic acid
T=50 - 60°C; 2.5 h;
2: With sodium hydroxide; sodium hydrogencarbonate in water
参考文献
Kuntz, Kevin; Emmitte, Kyle Allen; Rheault, Tara Renae; Smith, Stephon; Hornberger, Keith; Dickson, Hamilton; Cheung, Mui
Patent: US2008/300247 A1, 2008 ;
Location in patent: Page/Page column 53-54 ;
反应条件
potassium carbonate; tetrakis(triphenylphosphine) palladium(0); triphenylphosphine in toluene
T=100°C; Suzuki Coupling; 2 h;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2007/30361 A2, 2007 ;
Location in patent: Page/Page column 45 ;
WO 2007/030361 A2
